Evolutionary programming has originally been proposed for the breeding of nite state automata. The mutation operator is working directly on the graph structure of the automata. In this paper we introduce variation operators based on the automatons input/output behavior rather than its structure. The operators are designed to make use of additional information based on a ranking of states as wel...

Here we present a hybrid system that uses a reinforcement learning agent to improve the performance of a genetic algorithm on the travelling salesman problem (TSP). The agent uses Q(λ) learning to estimate state-action utility values, which it uses to implement high-level adaptive control over the genetic algorithm. In this way the agent influences selection of both crossover and mutation opera...

Homozygosis for the rd1 mutation in the Pbe6b gene results in the loss of the rod beta-subunit of the cyclic GMP phosphodiesterase and, eventually, of all rod and cone photoreceptors. The R6/2 mouse line is a widely used model of Huntington’s disorder (HD). The original line was made available on a mixed background obtained by crossing, via ovarian transplant, female R6/2 (on a B6CBA mixed back...

We present a new tierra-inspired artiicial life system with local interactions and two-dimensional geometry , based on an update mechanism akin to that of 2D cellular automata. We nd that the spatial geometry is conducive to the development of diversity and thus improves adaptive capabilities. We also demonstrate the adaptive strength of the system by breeding cells with simple computational ab...

Evolutionary programming has originally been proposed for the breeding of nite state automata. The mutation operator is working directly on the graph structure of the automata. In this paper we introduce variation operators based on the automatons input/output behavior rather than its structure. The operators are designed to make use of additional information based on a ranking of states as wel...

Due to the genetic mutation (fa) in gene encoding for leptin receptor, homozygous Zucker rats (fa−/−) develop excessive adiposity and become an experimental animal model obesity metabolic-related diseases research. Based on tetra-primer amplification refractory system-polymerase chain reaction (ARMS-PCR), we developed a method quickly genotype with mutated fa allele from their wildtype litterma...

Salinity is the most common abiotic stress against cultivated crops in world. Therefore, there are several ways to find out a possible solution this problem. Mutation breeding approach one of these elicit salinity tolerant varieties through induction beneficial mutations by applying mutagenic agents, either chemically or radiation. The current study was conducted apply gamma radiation as agent ...

Comparatively few studies have addressed directly the question of quantifying the benefits to be had from using molecular genetic markers in experimental breeding programmes (e.g. for improved crops and livestock), nor the question of which organisms should be mated with each other to best effect. We argue that this requires in silico modelling, an approach for which there is a large literature...

The main objective of this study was to assess insecticide contamination in Anopheles breeding habitats in urban residential areas and pyrethroid susceptibility status of mosquitoes found in the habitats. A larval survey was conducted in Akim Oda between July and October 2016. The larvae that were reared to adult were used for susceptibility test against four different pyrethroid insecticides (...