Cornelia de Lange syndrome (CdLS) is a rarely seen multisystem developmental disorder syndrome characterized by facial dysmorphia (arched eyebrows, synophrys, depressed nasal bridge, long philtrum, down-turned angles of the mouth), upper-extremity malformations, hirsutism, cardiac defects, growth and cognitive retardation, and gastrointestinal abnormalities. The features of this disorder vary w...

Here we describe a rare case of an abnormal karyotype with supernumerary derivative chromosome der(22)t(11;22), associated Emanuel syndrome, in boy aged 1 year. Familial cytogenetic analysis revealed the maternal origin anomaly from reciprocal translocation t(11;22) (q23;q11.2). At time examination, child had numerous anomalies development, facial dysmorphia, and small size external genitalia. ...

radiation-related wounds challenge surgeons in all disciplines of surgery. wound-healing complications are commonplace, and solutions for reconstruction are limited. muscle and musculocutaneous flaps have improved this situation. but the question is, does previous radiation of the muscle to be transposed affect the outcome? 143 consecutive previously irradiated patients treated with muscle or m...

Alagille syndrome is an inherited multisystem disorder of autosomal dominant transmission. Its prevalence estimated at 1 per 70,000 to 100,000 live births. We report the case a young patient suffering from who consulted center diagnosis and dental treatment Rabat - MOROCCO (CCTD). The general manifestations are facial dysmorphia, hepatic, cardiac, ocular disorders. Hepatic cholestasis causes or...