how to cite this article: khatami m, heidari mm, mansouri r, mousavi f. the polg polyglutamine tract variants in iranian patients with multiple sclerosis. iran j child neurol. 2015 winter; 9(1):37-41. abstract objective multiple sclerosis (ms) is a common disease of the central nervous system. the interaction between inflammatory and neurodegenerative processes typically results in irregular ne...

multiple sclerosis (ms) is an inflammatory disorder, in which neurons in central nervous system (cns) become demyelinated .ms is named for its formation of plaques due to sclerosis of myelin. variable degree of demyelination results in mild, mediate or severe symptomatic episodes of this disease. it is commonly characterized by recurrent relapses and often followed by severe neurological disabi...

background: multiple sclerosis is a common and chronic neurologic disorder. this disorder imposes physical, economic, and psychosocial burden on individuals, their families and society. this study aims to analyze the costs of multiple sclerosis disease based on the severity of disability. methods: we performed a cross‑sectional cost of illness study. this study was conducted in 332 patients of ...

Multiple sclerosis (MS) is a chronic, autoimmune disease affecting the central nervous system. The disease targets the myelin sheaths around nerves, leading to inflammation, myelin loss, and axonal destruction. MS is the most common cause of neurologic disability in people between the ages of 20 and 40. There are approximately 400,000 cases of MS in North America and approximately 2.5 million w...

The diagnostic criteria for multiple sclerosis (MS) are based on a combined evaluation of clinical symptoms and MRI findings [1]. The MRI criteria for multiple sclerosis introduced by Swanton et al. take location and distribution as well as configuration, number and contrast behavior of MS lesions into account [2]. In more recent studies, perivenous distribution of multiple sclerosis lesions ha...

a prior history of healthy lifestyle may be misleading when we consider associated risk factors for developing a serious and debilitating condition such as multiple sclerosis under extreme stress. the author reports a case of a woman who lived a healthy life and yet experienced an unexpected event leading to the diagnosis of multiple sclerosis. the patient’s condition was predominantly provoked...

Sjogren-Larsson Syndrome (SLS) is an inherited autosomal recessive neurocutaneous disorder with congenital ichthyosis, spastic diplegia or quadriplegia and mental retardation. We report a case of Sjogren-Larsson Syndrome with clinical profile (mental retardation, ichthyosis, spastic diplegia) and MRI findings such as seen in multiple sclerosis (MS). So this rare syndrome can be another differen...

Introduction: To protect genomes of all organisms from internal and external damages and maintain the genome integrity and the continuity of life, repair system has been developed in all living cells. Defects in repair system are responsible for various kinds of disease including cancers and neurodegenerative diseases such as Multiple sclerosis (MS). The relationship between various compone...

background: hormones can play a significant role in the pathogenesis of multiple sclerosis (ms). the aim of this study was to compare levels of ghrelin, leptin, and testosterone hormones of ms patients with healthy subjects, and assess the relationship between levels of peptide hormone and sex hormones in ms patients. methods: 35 ms patients with definite relapsing remitting multiple sclerosis ...