In this paper, we describe new integer linear programming models and algorithms for datapath scheduling that aim at minimizing peak power while maintaining performance. The first algorithm, MVDFC combines both multiple supply voltages and dynamic frequency clocking for peak power reduction, while the second algorithm, MVMC explores multiple supply voltages and multicycling. The algorithms use t...

Systematic mappings of the effects of protein mutations are becoming increasingly popular. Unexpectedly, these experiments often find that proteins are tolerant to most amino acid substitutions, including substitutions in positions that are highly conserved in nature. To obtain a more realistic distribution of the effects of protein mutations, we applied a laboratory drift comprising 17 rounds ...

A recently proposed approximate maximum-likelihood estimator (MLE) of multiple exponentials converts the frequency estimation problem into a problem of estimating the coefficients of a :-polynomial with roots at the desired frequencies. Theoretically, the roots of the estimated polynomial should fall on the unit circle, but MLE, as originally proposed, does not guarantee unit circle roots. This...

The rational design of photonic nanostructures consists of anticipating their optical response from systematic variations of simple models. This strategy, however, has limited success when multiple objectives are simultaneously targeted, because it requires demanding computational schemes. To this end, evolutionary algorithms can drive the morphology of a nano-object towards an optimum through ...