In this tutorial, we describe a new framework for representing and synthesizing knowledge from clinical trials involving multiple outcome indicators. The framework offers a formal approach to aggregating clinical evidence. Based on the available evidence, arguments are generated for claiming that one treatment is superior, or equivalent, to another. Evidence comes from randomized clinical trial...

Many ways exist to measure and model financial asset volatility. In principle, as the frequency of the data increases, the quality of forecasts should improve. Yet, there is no consensus about a “true” or "best" measure of volatility. In this paper we propose to jointly consider absolute daily returns, daily high-low range and daily realized volatility to develop a forecasting model based on th...

respectively), it has not been subjected to the Agency's required peer and policy review and therefore does not necessarily reflect the views of the Agency and no official endorsement should be inferred. Executive Summary The Estuarine and Great Lakes (EaGLe) program was established to develop a suite of new, integrative indicators of ecological condition for the coastal zones of the contiguous...