multiple sclerosis (ms) is a demyelinating neuro- inflammatory autoimmune disease of the central nervous system. genetic predisposition has long been suspected in the etiology of this disease. the association between mthfr polymorphisms and ms has been ivestigated in different ethnic groups. we investigated the association between mthfr c677t and a1298c missense variants and ms in 180 patients ...

background: hormones can play a significant role in the pathogenesis of multiple sclerosis (ms). the aim of this study was to compare levels of ghrelin, leptin, and testosterone hormones of ms patients with healthy subjects, and assess the relationship between levels of peptide hormone and sex hormones in ms patients. methods: 35 ms patients with definite relapsing remitting multiple sclerosis ...

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abstract objective: according to the previous studies, 2-5 percent of patients with multiple sclerosis experienced the first episode of disease before the age 16.  since the age of onset among children is not similar to that in general population, clinicians often fail to early diagnose the disease. this study aims to determine the epidemiological and clinical patterns of ms among iranian child...

a bstract       background:  patients with multiple sclerosis experience hospitalization several times in their lives. certainly, providing ef fi cient and high-quality care by healthcare professionals is not possible unless the experiences of patients’ hospitalization are taken into consideration. this qualitative study was aimed to identify experiences of patients with multiple sclerosis in t...

conclusions herpes simplex virus was present in more patients with ms than healthy cases. hsv may be directly or indirectly associated with ms development. further comprehensive molecular studies are needed to confirm the etiopathologic association between hsv and ms disease. results totally, 63 (76.8%) patients with ms showed a history of hsv exposure by anti-hsv testing compared to 70 (78.7%)...

conclusions the prevalence of ms showed an increasing rate of the disease in recent years. decreasing of the female to male ratio and patients’ low socio-economic level, need more studies. the increasing rate of patients with progressive relapsing feature and more disabled patients belong to this subtype show the poor prognosis. results a total of 142 patients were participated in this study. p...

conclusions the findings suggested that according to the ecological conditions of ahvaz, a family history of ms may increase the risk of developing ms. results in both cases and controls, no significant associations were found between arab ethnicity and incidence of ms, marital status and risk of ms in ahvaz, or more than 15-year residency in ahvaz, birth in khuzestan, and month of birth and th...

multiple sclerosis is a chronic inflammatory disease of central nervous system.women are more susceptible to this disease. one of the obvious clinical complaints in women with multiple sclerosis specially treated with beta interferones is menstrual cycle irregularity. the aim of this study was to determine the prevalence of menstrual irregularities and probable changes in blood levels of relate...