The voltage-gated sodium (Na(v)) channel is a target for a number of drugs, insecticides and neurotoxins. These bind to at least seven identified neurotoxin binding sites and either block conductance or modulate Na(v) channel gating. A number of peptide neurotoxins from the venoms of araneomorph and mygalomorph spiders have been isolated and characterized and determined to interact with several...

Transgenic mice were produced that carried in their germlines rearranged kappa and/or mu genes with V kappa and VH regions from the myeloma MOPC-167 kappa and H genes, which encode anti-PC antibody. The mu genes contain either a complete gene, including the membrane terminus (mu genes), or genes in which this terminus is deleted and only the secreted terminus remains (mu delta mem genes). The m...

1 A Dantzig-Wolfe Decomposition-Based Heuristic for Off-line Capacity Calibration of Dynamic Traffic Assignment / D.-Y. Lin. V. Vatsaraj, S.T. Waiter 16 Influence of Demand Uncertainty and Correlations on Traffic Predictions and Decisions / J.C. Duthie.A. Unnikrishnan, S.T. Waiter 30 Peak Ground Acceleration Estimation by Linear and Nonlinear Models with Reduced Order Monte Carlo Simulation / K...

objectives: the aim of this study was to verify the treatment planning systems (tpss). the next aim was to validate imsure qa software for patient-specific qa in radiotherapy clinics.  material and methods: we used imsure qa software (standard imaging, v 3.5) for verification of 92 non-imrt plans (540 fields) in 10 radiotherapy clinics. to validate the imsure, dose measurement was performed in ...

We give a new region of existence of solutions to the superhomogeneous Dirichlet problem (SR) −∆pu = v δ v > 0 in B, −∆qv = u μ u > 0 in B, u = v = 0 on ∂B, where B is the ball of radius R > 0 centered at the origin in R . Here δ, μ > 0 and ∆mu = div(|∇u| ∇u) is the m−Laplacian operator for m > 1.

We studied mu-opioid transmission in acute slices of rat neocortex using whole-cell recordings and single-cell reverse transcription-polymerase chain reaction. The mu-opioid receptor (MOR) was found in gamma-aminobutyric acidergic (GABAergic) interneurons that were either layer I cells frequently expressing neuropeptide Y or layers II-V cells expressing vasoactive intestinal peptide and enkepha...

DNA polymerase mu (pol mu), which is related to terminal deoxynucleotidyl transferase and DNA polymerase beta, is thought to be involved in non-homologous end joining and V(D)J recombination. Pol mu is induced by ionizing radiation and exhibits low fidelity. Analysis of translesion replication by purified human pol mu revealed that it bypasses a synthetic abasic site with high efficiency, using...

We consider a one-dimensional run-and-tumble particle, or persistent random walk, in the presence of an absorbing boundary located at origin. After each tumbling event, which occurs constant rate $\gamma$, (new) velocity particle is drawn randomly from distribution $W(v)$. study survival probability $S(x,t)$ starting $x \geq 0$ up to time $t$ and obtain explicit expression for its double Laplac...

Mutator activity of the Mu mutator system of maize can be lost by either outcrossing or inbreeding Mu stocks. The nature of these two kinds of Mu-loss phenomena was analyzed by testing the results of crossing Mu-loss stocks by active Mu lines. Outcross-Mu-loss stocks are capable of supporting Mu activity if crossed by an active mutator line. Inbred-Mu-loss stocks, however, inactivate the active...

We consider an extension of the mu-calculus as a general framework to describe and synthesize controllers. This extension is obtained by quantifying atomic propositions, we call the resulting logic quanti ed mu-calculus. We study its main theoretical properties and show its adequacy to control applications. The proposed framework is expressive : it o ers a uniform way to describe as varied para...