In this paper, we describe the processing and verification work undertaken to migrate WordStar for MSDOS to HTML4 formatted files. General Terms Preservation strategies and workflows, specialist content types, digital preservation marketplace, theory of digital preservation, case studies and best practice.

BACKGROUND Glatiramer acetate therapy is thought to be effective for multiple sclerosis (MS) by promoting T(H)2 cytokine deviation, possibly in the brain, but the exact mechanism and site of action are incompletely understood. Determining the site of action and effect of glatiramer on cell trafficking is of major importance in designing rational combination therapy clinical trials. OBJECTIVE ...

Objective. Examine the impact of comorbid depression on adherence to disease-modifying therapy (DMT) for multiple sclerosis (MS). Methods. A retrospective database was used to identify patients with MS treated with a DMT. Patients with MS and comorbid depression were matched to patients with MS only. Adherence to DMT was proxied by the medication possession ratio (MPR) and multivariate regressi...

Piracetam was subjected to the hydrolytic, oxidative, thermal and photolytic stress, according to ICH guideline Q1A (R2). The drug depicted degradation only in basic conditions, while it was stable to other stress conditions (acidic, neutral hydrolysis, thermal and photolytic conditions). A total of one degradation product was formed, which were separated on a BEH column employing an isocratic ...

Atypical or idiosyncratic language is a characteristic of autism spectrum disorder (ASD). In this paper, we discuss previous work identifying language errors associated with atypical language in ASD and describe a procedure for reproducing those results. We describe our data set, which consists of transcribed data from a widely used clinical diagnostic instrument (the ADOS) for children with au...

I. Introduction: In Multiple Sclerosis (MS) neither the pathogenesis of the disease nor the mechanism of an action of immunomodulating therapies (IMT " S) are fully understood [1,2,3]. Genetic predispositions, socioeconomic influences, gender (females: males = 2:1), infectious agents, and other environmental factors have been implicated [4,5]. Identifying treatment has been challenging since th...

Aims. To determine the progression of body weight (BW) and body composition (BC) in patients with type 2 diabetes mellitus (T2D) on insulin therapy and the consequences on muscle strength (MS) as a reflect of free fat mass increases. Research design and methods. We analysed BC using air displacement plethysmography and MS by hand grip dynamometry in 40 T2D before and after three (M3) and six mo...

BACKGROUND No intervention has proven effective in modifying long-term disease prognosis in Multiple Sclerosis (MS) but exercise therapy is considered to be an important part of symptomatic and supportive treatment for these patients. OBJECTIVES To assess the effectiveness of exercise therapy for patients with MS in terms of activities of daily living and health-related quality of life. SEA...

P eople with multiple sclerosis (MS) face a wide variety of physical, emotional, and social challenges. A multidisciplinary comprehensive care approach is recommended for the management of MS and its consequences, and non-traditional treatments are increasingly considered by patients and health care providers, particularly for the promotion of wellness in the context of this chronic disease. Pr...

BACKGROUND AND PURPOSE There is still no curative treatment for multiple sclerosis (MS), but during the last 20 years eight different disease-modifying compounds have been approved for relapsing-remitting MS (RRMS). METHODS A literature search was conducted on published randomized controlled phase III trials indexed in PubMed on the approved medications until 21 May 2015. RESULTS In this re...