of Dissertation Presented to the Graduate School of the University of Florida in Partial Fulfillment of the Requirements for the Degree of Doctor of Philosophy DIFFUSION MAGNETIC RESONANCE IMAGING IN A RAT HIPPOCAMPAL SLICE MODEL OF ACUTE BRAIN INJURY By Timothy Michael Shepherd May 2003 Chair: Edward D. Wirth, III Major Department: Neuroscience This dissertation describes experiments using rat...

Diffusion tensor imaging (DTI) is a magnetic resonance modality that permits to characterize the orientation and integrity of white matter (WM). DTI-based tractography techniques, allowing the virtual reconstruction of WM tract pathways, have found wide application in preclinical neurological research. Recently, anatomically detailed rat brain atlases including DTI data were constructed from ex...

To obtain a database of accurate anatomical images onto which dosimetry data of electromagnetic fields could be mapped, a healthy Sprague-Dawley rat, rhesus monkey, and pigmy goat were scanned using magnetic resonance imaging (MRI). Axial sections throughout the length of the animals were collected. Sections were 3 mm thick for the rat and 5 mm thick for the monkey and goat. Sagittal sections (...

Mild traumatic brain injury typically involves temporary impairment of neurological function. Previous studies used the water pressure or rotational injury for designing the device to make a rat mild traumatic brain injury model. The objective of this study was to make a simple model of mild traumatic brain injury in rat. The device consisted of a freefall impactor that was targeted onto the ra...

INTRODUCTION Earlier work indicates that the cholesterol-lowering drug, simvastatin, is anabolic to chondrogenic expression of rat intervertebral disc (IVD) cells, which suggests a potential role for simvastatin in IVD regeneration. In this study, we expand on our earlier work to test the effectiveness of simvastatin on disc degeneration utilizing a rat tail disc degeneration model. METHODS 3...

Integration of imaging data with immunohistology is a new art. Increased PET and MRI image intensities on rat breast tumor MRI-PET images were reviewed for possible correlation with tumor histology and MALDI imaging tumor characteristics in the light of recent inventions and patents. Increased signal intensities of intracellular (IC) sodium MRI and flouro-2-deoxy-glucose utilization by PET from...

Numerous magnetic resonance images (MRI)-derived brain atlases are available online for multiple species (Bakker et al., 2015). MRI-derived rat brain atlases have been produced for different purposes using different procedures. The largest number of atlases appear to have been derived for morphometric purposes, e.g., white matter – gray matter segmentation (Valdes-Hernandez et al., 2011), volum...

detection of brain tissues using magnetic resonance imaging (mri) is an active and challenging research area in computational neuroscience. brain mri artifacts lead to an uncertainty in pixel values. therefore, brain mri segmentation is a complicated concern which is tackled by a novel data fusion approach. the proposed algorithm has two main steps. in the first step the brain mri is divided to...

background: to retrospectively describe imaging characteristics of liver metastases on fused fdg-pet/ mri data sets and to compare the diagnostic accuracy of mri and fused fdg-pet/mri data sets for the detection of liver metastases in patients undergoing systemic anticancer treatment. materials and methods: 43 oncological patients (mean age: 56+/- 11 years) were investigated by fdg-pet/ct and l...