BACKGROUND Accurate tumor bed delineation after breast-conserving surgery is important. However, consistency among observers on standard postoperative radiotherapy planning CT is low and volumes can be large due to seroma formation. A preoperative delineation of the tumor might be more consistent. Therefore, the purpose of this study was to determine the consistency of preoperative target volum...

Abstract AIMS Imaging of tumour habitats is a novel technique to assess regional treatment response by defining ‘habitats’, which are regions with shared imaging characteristics. Here, we describe pipeline characterise in glioblastoma using bioinformatics and machine learning. We apply this patients the Preoperative Brain Irradiation Glioblastoma (POBIG) trial that received preoperative radioth...

BACKGROUND Radiotherapy, preferably combined with chemotherapy, is the treatment standard for locally advanced, unresectable non-small cell lung cancer (NSCLC). The tumor response to different therapy protocols is variable, with hypoxia known to be a major factor that negatively influences treatment effectiveness. Visualisation of tumor hypoxia prior to the use of modern radiation therapy strat...

R. H. Ireland, M. McJury, M. Q. Hatton, N. Woodhouse, E. J. van Beek, J. M. Wild Academic Unit of Radiology, University of Sheffield, Sheffield, United Kingdom, Belvoir Park Hospital, Belfast, United Kingdom, Weston Park Hospital, Sheffield, United Kingdom, Carver College of Medicine, University of Iowa, Iowa City, IA, United States Introduction For patients with non-small cell lung cancer (NSC...

OBJECTIVES AND DESIGN We performed a prospective study using magnetic resonance imaging (MRI) at regular post-operative intervals in non-irradiated patients with non-functioning pituitary adenomas (NFAs) to assess the frequency of tumoral regrowth and recurrences, in order to define the indications of post-operative radiotherapy. PATIENTS AND METHODS Fifty-one patients aged 25--80 years (mean...

A critical step in radiotherapy treatment planning process is to accurately locate the tumor and determine its extent. Variability in gross tumor volume (GTV) delineation is a major source of systematic error in conformal radiotherapy. CT scan is the principle source of imaging data used for defining GTV for planning conformal therapy. CT is widely available less costly and compatible with radi...

Desmoid fibromatosis of the breast is extremely rare. It characterized by high locally aggressive potential but does not have a metastatic power. We report case 52-year-old patient with desmoid tumor on ground rectocolic polyposis. MRI has an important place in diagnostic strategy while confirmation done pathological examination. The initial treatment surgical excision other therapeutic choices...

PURPOSE To report the incidence of and risk factors for mastoiditis after intensity-modulated radiotherapy (IMRT) in nasopharyngeal carcinoma (NPC). PATIENTS AND METHODS Retrospective analysis of pretreatment and follow-up magnetic resonance imaging (MRI) data for 451 patients with NPC treated with IMRT at a single institution. The diagnosis of mastoiditis was based on MRI; otomastoid opacifi...

background: accurate small radiation field dosimetry is essential in modern radiotherapy techniques such as stereotactic radiosurgery (srs) and intensity modulated radiotherapy (imrt). precise measurement of dosimetric parameters such as beam profile, percentage depth doses and output factor of these beams are complicated due to the electron disequilibrium and the steep dose gradients. in the p...