rachytherapy, the treatment of cancer patients by placing sealed radioactive elements at the short distances relative to the tumor, was born soon after Henri Becquerel’s discovery of radioactivity in Paris (1896) and Marie Curie’s discovery of radium (1898). However, within the past several years there have been great improvements in the technical aspect of the brachytherapy procedures (Blasko ...

INTRODUCTION We describe five patients receiving a re-implantation (RI) after post-operative dosimetry of the primary 125-I permanent prostate brachytherapy (BT) for prostate cancer revealed an insufficient dose coverage. MATERIALS AND METHODS Five out of 222 consecutive patients treated (from March, 2001 to August, 2012) with 125-I BT, received a RI after dosimetric verification by CT and MR...

The polymer gel-Magnetic Resonance Imaging (MRI) dosimetry technique was employed to evaluate the mechanical and dose delivery accuracy in Leksell gamma knife stereotactic radiosurgery for the treatment of multiple targets. Two different polymer gel dosimeter formulations that have been reported in the literature were prepared in-house. A plan for the treatment of four brain metastases (targets...

Introduction Brachytherapy is a common radiation treatment option for prostate cancer, in which many small radioactive seeds are implanted into the prostate gland under image guidance [1]. Precise knowledge of the prostate volume and the distribution of the seeds are required for accurate radiotherapy dosimetry. Imaging modalities like 2D X-ray or computed tomography allow precise seed localiza...

The purpose of the present study was to investigate the threshold dose for focal liver damage after stereotactic body radiation therapy (SBRT) in cirrhotic and normal livers using magnetic resonance imaging (MRI). A total of 64 patients who underwent SBRT for liver tumors, including 54 cirrhotic patients with hepatocellular carcinoma (HCC) and 10 non-cirrhotic patients with liver metastases, we...

BACKGROUND Restenosis is a serious complication of coronary angioplasty that involves the proliferation and migration of vascular smooth muscle cells (VSMCs) from the media to the intima, synthesis of extracellular matrix, and remodeling. We have previously demonstrated that tissue factor-targeted nanoparticles can penetrate and bind stretch-activated vascular smooth muscles in the media after ...

Over the course of the last decade, routine monitoring of the alanine dosimetry system revealed a small but significant observation that, after examination, led to the characterization of a previously unknown absorbed-dose-dependent, dose-rate effect for the alanine system. The newly discovered rate effect is of potential concern for electron-beam dosimetry, since electron-beam dosimetry typica...

Currently, the use of blood irradiation for inactivating pathogenic microbes in infected blood products and preventing graft-versus-host disease (GVHD) in immune suppressed patients is greater than ever before. In these systems, dose distribution and uniformity are two important concepts that should be checked. In this study, dosimetry of the gamma chamber blood irradiator model Gammacell 3000 ...