Literature addressing master production scheduling (MPS) typically focuses on the development of sophisticated MPS methods with the expectation that these methods will result in feasible plans and improved performance. However, empirical evidence showing that sophisticated methods are better than simpler ones remains scarce, and companies have reported difficulties with using sophisticated plan...

BACKGROUND Undiagnosed patients with the attenuated form of mucopolysaccharidosis (MPS) type I often have joint symptoms in childhood that prompt referral to a rheumatologist. A survey conducted by Genzyme Corporation of 60 European and Canadian rheumatologists and pediatric rheumatologists demonstrated that < 20% recognized signs and symptoms of MPS I or could identify appropriate diagnosis te...

After the first description of a patient recognized as a MPS case was made in 1917, several similar cases were described and identified. Observations reported in the middle of the twentieth century concerning the presence of acid mucopolysaccharides (later called glycosaminoglycans, or GAGs) in tissues and especially in urine of patients were instrumental in providing an identity for these dise...

The ERNDIM Urine Mucopolysaccharide scheme is aiming at (1) provision of urine samples obtained from confirmed MPS patients to enable laboratories to gain or maintain experience to identify MPS patients and (2) proficiency testing of laboratories providing urine screening of mucopolysaccharidosis. The scheme is organised by Erasmus Medical Centre (Rotterdam, NL) in conjunction with SKML, the Du...

PULMONARY EDEMA FLUID is not just water but is instead a complex biological medium. The daedal nature and variability of its makeup are particularly apparent when samples of alveolar edema or bronchoalveolar lavage fluid from patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) are examined compared with those from subjects with hydrostatic (“cardiogenic”) pulmonary ...

BACKGROUND Microparticles (MPs) are released from the plasma membrane of activated or dying cells and bear surface molecules from those cells. We examined whether donor-derived MPs in the peripheral blood of the recipient could serve as a marker of tissue damage due to rejection of a transplanted hand. METHODS Platelet-free plasma from the recipient of the transplanted hand was analyzed for M...

The effect of the Shwartzman phenomenon on the metabolism of the acid mucopolysaccharides (MPS), hyaluronic acid and chondroitin sulfate, from rabbits with localized lesions was studied. Quantitative changes of MPS were observed by two techniques-the in vivo incorporation of glucose C(14) into the MPS and the in vitro dilution of C(14)-labeled MPS. The results indicate an increased concentratio...

This study included 18 cases with hepatomegaly referred to the Human Genetics Department, National Research Centre with a suspicion of a metabolic disorder from 2006 to 2008. The aim of our study was to find out the importance of hepatomegaly as sign for many metabolic disorders and their frequency among other disorders with hepatomegaly. All cases were subjected to clinical and biochemical stu...

The mechanisms of action of mineral phosphate solubilization (MPS) were studied in the wild-type Mps‡ Penicillium rugulosum strain IR94-MF1 and in negative (Mps3) and superpositive (Mps‡‡) mutants derived from it. MPS activities were measured in liquid media using sucrose as C source, four N (arginine, nitrate, nitrate+ammonium and ammonium) and P sources (KH2PO4, hydroxyapatite, FePO4 and AlPO...

The maximum product of spacings (MPS) is employed in the estimation of the Generalized Extreme Value Distribution (GEV) and the Generalized Pareto Distribution (GPD). Efficient estimators are obtained by the MPS for all γ. This outperforms the maximum likelihood method which is only valid for γ < 1. It is then shown that the MPS gives estimators closer to the true parameters compared to the max...