نتایج جستجو برای: mouse testis

تعداد نتایج: 299673  

Journal: :Frontiers in bioscience 2012
Yanjun Zhang Yi Du Dengyu Wang Renwei Jing Weihua Kong

Prostaglandins have important roles in the male reproductive system. In this study, we report on the distribution and regulation of cPGES during postnatal development of mouse testis. The expression of cPGES was weak in testis 5 days after birth and increased through the 10th and 15th day. From the 20th day onward, the cPGES expression in testis reached the level of adult mice. cPGES was expres...

2002

Male differentiation is triggered by mal gene coding for a zinc finger protein (termed a Y chromosomal gene, termed TDF. During the ZFY) was isolated from the testis determining last 25 yr several hypotheses have been formuregion of the human and mouse Y chromosome. lated regarding the nature of TDF and its gene Due to its location and possible function as a product. Serologically detectable H-...

2011

WNT signalling plays a central role in mammalian sex determination by promoting ovarian development and repressing aspects of testis development in the early gonad. Dickkopf homolog 1 (DKK1) is a WNT signalling antagonist that plays critical roles in multiple developmental systems by modulating WNT activity. Here, we examined the role of DKK1 in mouse sex determination and early gonadal develop...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2003
Jennifer LeCouter Rui Lin Max Tejada Gretchen Frantz Franklin Peale Kenneth J Hillan Napoleone Ferrara

We recently identified an angiogenic mitogen, endocrine-gland-derived vascular endothelial growth factor (EG-VEGF), with selective activity for endothelial cells of endocrine tissues. Here we describe the characterization of a highly related molecule, Bv8, also known as prokineticin-2. Human Bv8 shares 60% identity and 75% similarity with EG-VEGF. The human and mouse Bv8 genes share a common st...

2013
Daniel Murta Marta Batista Elisabete Silva Alexandre Trindade Domingos Henrique António Duarte Luís Lopes-da-Costa

The transcription and expression patterns of Notch pathway components (Notch 1-3, Delta1 and 4, Jagged1) and effectors (Hes1, Hes2, Hes5 and Nrarp) were evaluated (through RT-PCR and IHC) in the mouse testis at key moments of post-natal development, and along the adult spermatogenic cycle. Notch pathway components and effectors are transcribed in the testis and expressed in germ, Sertoli and Le...

جمالی, زینب , رضی‌پور, معصومه , علوی‌نژاد, الهه , مدرسی, محمد حسین , میریونسی, سید محمد ,

Background: About 15% of couples have fertility problems and male factor in fertility accounts for half of the cases. In vitro generation of germ cells introduces a novel approach to male infertility and provides an effective system in gene tracking studies, however many aspects of this process have remained unclear. We aimed to promote mouse embryonic stem cells (mESCs) differentiation into ge...

Journal: :Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation 2011
A N Combes J Bowles C-W Feng H S Chiu P-L Khoo A Jackson M H Little P P L Tam P Koopman

WNT signalling plays a central role in mammalian sex determination by promoting ovarian development and repressing aspects of testis development in the early gonad. Dickkopf homolog 1 (DKK1) is a WNT signalling antagonist that plays critical roles in multiple developmental systems by modulating WNT activity. Here, we examined the role of DKK1 in mouse sex determination and early gonadal develop...

Journal: :Cold Spring Harbor Symposia on Quantitative Biology 2008

Journal: :Molecular Medicine Reports 2010

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