in the present study, interactions of dopamine receptor agonists and antagonists with water swimming stress (wss) on naloxone-induced jumping in morphine-dependent mice were examined. mice were rendered dependent as described in the methods section. the opioid receptor antagonist, naloxone (1 mg/kg), was injected to elicit jumping (as a withdrawal sign). the first group exposed to wss in the pr...

lead is an ubiquitous environmental toxin that induces a broad range of physiological biochemical, and behavioral dysfunctions. in this study, we examined the pathologic effects of lead acetate in nmri mouse ovarian tissue and the protective role of antioxidant l-cysteine, against the induced damage. we used lead acetate at a dose of 10 mg/kg, and l-cysteine at a dose of 200 mg/kg. both drugs w...

organotypic spinal cord slices from neonatal mammals could be a powerful model for evaluation of cell survival but also cell death mechanisms. the aim of this study was to establish an in vitro model for investigating cell survival and mechanism involved in cell death in neonatal spinal cord slices. the spinal cord was sliced and incubated into culture medium. the mtt assay was carried out to a...

three subspecies of mus musculus have been recognized in iran so far. the house mouse (genus0t 0t2tmus2t, species0t 0t2tmus musculus2t) are recognized for their highly conserved morphology and chromosomal structure, but some chromosomal characters offer accurate taxonomic markers in this species that has been shown any unambiguous diagnostic morphological traits. among the chromosomal character...

objective: to determine bilateral effects of unilateral iatrogenic vas deferens trauma (uit) on epididymal sperm characteristics and in vitro fertilizing capacity in an experimental mouse model. methods: experiments were performed on three equal groups each comprising six adult male mice. following anaesthesia, uit was induced by clamping left vas deferens with a mosquito clamp in fully locked ...

this study was aimed to assess the protective effects of cornus mas fruit extract (cmfe) and vitamin e (vit e) on sperm quality parameters in the methotrexate (mtx)-treated mice. forty-eight young adult male mice (8-12 weeks) were randomly divided into six groups including control and test groups. the control group received normal saline orally , and the test groups were treated mtx (20 mg kg-1...

background: the expression of mouse tumor necrosis factor alpha (tnf-α) in escherichia coli is a favorable way to get high yield of protein; however, the formation of cytoplasmic inclusion bodies, which is the consequence of insoluble accumulated proteins, is a major obstacle in this system. to overcome this obstacle, we used a pulsed dilution method to convert the product to its native conform...

background: leptin and adiponectin are the two key metabolic hormones secreted from adipocytes to control food intake and energy expenditure. the action of both hormones in regulation of gonadotropin releasing hormone (gnrh) secretion from the hypothalamus is mediated through kisspeptins. kisspeptins are products of kiss-1 gene. leptin and adiponectin are modulators of kiss-1 expression in the ...

givotia rottleriformis has been used in the indigenous systems of medicine for the treatment of inflammatory diseases like rheumatism and psoriasis. in order to evaluate this information, antipsoriatic activity of three flavonoids isolated from the ethanol extract of the bark of givotia rottleriformis were investigated using in-vitro and in-vivo model, namely rutin (i), luteolin-7-o-β-d-glucuro...