Faithful execution of developmental gene expression programs occurs at multiple levels and involves many different components such as transcription factors, histone-modification enzymes, and mRNA processing proteins. Recent evidence suggests that nucleoporins, well known components that control nucleo-cytoplasmic trafficking, have wide-ranging functions in developmental gene regulation that pot...

Managerial leadership is most indispensable for growth of any organization. Especially HR leaders play a critical role the success business They must be much innovative, strategic and commanding while redressing raised grievances various employees. Their creative advice bear motivational spirit by using emotional intelligence. HRM personnel need tranquil with powerful personality to solve inter...

Objective: Importance of management of gardens weeds is an issue that unfortunately has less been investigated by weeds researchers of country. One of the most important restrictive agents of cultivated surface and producing crops of Citrus orchards are weeds. Methods: In this investigation, isolates of Fusarium solani were recovered from diseased broomrape collected from toma...

in this study, bio-based carbon nanotubes (cnts) have received considerable research attention due to their comparative advantages of high level stability, simplistic use, low toxicity and overall environmental friendliness. new potentials for improvement in heat transfer applications are presented due to their high aspect ratio, high thermal conductivity and special surface area. phonons have ...

Glucagon and insulin are first detectable at the onset of rat pancreas organogenesis. Initially, the specific activity of glucagon is approximately 100-fold higher than that of insulin. At this early stage, endocrine storage granules, similar to alpha granules, are identifiable in electron micrographs. The granule characteristics, as well as the relative hormone levels, suggest that the early p...

Nonsynonymous single nucleotide variants (nsSNVs) constitute about 50% of known disease-causing mutations and understanding their functional impact is an area of active research. Existing algorithms predict pathogenicity of nsSNVs; however, they are unable to differentiate heterozygous, dominant disease-causing variants from heterozygous carrier variants that lead to disease only in the homozyg...

Background: Despite clear reasons for necessity of sexual health education for adolescents, it is a contested issue and has faced challenges in most cultures. Adolescents, specially females in Iran have so many unmet needs in sexual health issues, yet appropriateness of sexual health education to them is controversy. This study aimed to examine female adolescents attitudes to sexual health educ...

“I Want to, But I Also Need to”: Start-Ups Resulting from Opportunity and Necessity When unemployed persons go into business, they often are characterized as necessity entrepreneurs, because push factors, namely their unemployment, likely prompted their decision. In contrast to this, business founders who have been previously employed represent opportunity entrepreneurs because pull factors pro...

The neurotransmitters dopamine (DA) and glutamate in the striatum play key roles in movement and cognition, and they are implicated in disorders of the basal ganglia such as Parkinson's disease. Excitatory synapses in striatum undergo a form of developmental plasticity characterized by a decrease in glutamate release probability. Here we demonstrate that this form of synaptic plasticity is DA a...

Chromatin structure and its changes or maintenance throughout developmental checkpoints play indispensable role in organismal homeostasis. Chromatin remodeling factors of the SWI/SNF2 superfamily use ATP hydrolysis to change DNA-protein contacts, and their loss-of-function or inappropriate increase leads to distinct human pathologic states. In this review, we focus on the translational view of ...