BACKGROUND A recurring epidemic of asthma exacerbations in children occurs annually in September in North America when school resumes after summer vacation. OBJECTIVE Our goal was to determine whether montelukast, added to usual asthma therapy, would reduce days with worse asthma symptoms and unscheduled physician visits of children during the September epidemic. PATIENTS AND METHODS A tota...

BACKGROUND The aim of our study was to investigate effects of 6-week pretreatment of seasonal allergic rhinitis (AR) with cetirizine, and montelukast, alone and in combination. Antihistamine/antileukotriene treatment is effective in AR. Antihistamines may prevent AR symptoms while prophylactic activity of antileukotrienes remains unclear. METHODS Sixty AR patients, aged 18-35 years, were rand...

AIMS Compare the effects of montelukast or dexamethasone in distal lung parenchyma and airway walls of guinea pigs (GP) with chronic allergic inflammation. METHODS GP have inhaled ovalbumin (OVA group-2x/week/4weeks). After the 4th inhalation, GP were treated with montelukast or dexamethasone. After 72 hours of the 7th inhalation, GP were anesthetised, and lungs were removed and submitted to ...

A new stability-indicating RP-HPLC method was developed for the simultaneous determination of fexofenadine hydrochloride and montelukast in combined dosage form, using a Aligent, Zorbax (Make: 150 mmx4.6 mm I.D; particle size 5μm and a mobile phase composed of phospahte buffer (pH 4.0): Acetonitile (60:40 v/v) at a flow rate of 1.0mL/min. The retention times of fexofenadine hydrochloride and mo...

Aphthous ulcers are the most prevalent oral mucosal lesions, yet treatment is challenging. There evidence that montelukast efficacious in treating aphthous ulcers. A randomized placebo-controlled trial comparing against prednisone for recurrent stomatitis demonstrated has superior efficacy compared with placebo, decreased prednisone, but adverse effects to prednisone. Our single-center, retrosp...

A simple, specific, accurate, and stability-indicating reversed-phase high-performance liquid chromatographic method was developed for the simultaneous determination of montelukast and fexofenadine hydrochloride, using a Lichrospher(®) 100, RP-18e column and a mobile phase composed of methanol:0.1% o-phosphoric acid (90:10 v/v), pH 6.8. The retention times of montelukast and fexofenadine hydroc...

Quantitative image analysis of high-resolution computed tomography (HRCT) performed at residual volume, before and after methacholine, is a sensitive method of detecting small airways involvement in asthma and response to therapy targeted to the small airways. Since an oral anti-leukotriene reaches the small airways via the circulation, the present authors hypothesised that treatment with monte...

The PREVIA study was designed to investigate the role of montelukast, a leukotriene receptor antagonist, in the prevention of viral-induced asthma exacerbations in children aged 2 to 5 years with a history of intermittent asthma symptoms. The study was a 12-month multicenter, double-blind, parallel-group study of patients with asthma exacerbations associated with respiratory infections and mini...

The Montelukast pulsatile delivery system was created with the goal of delivering drug to colon for successful treatment nocturnal asthma. microspheres were sealed within insoluble hard gelatin capsule body an erodible hydrogel plug create a time delayed capsule. Emulsion solvent evaporation used make microspheres. Based on dissolving tests, optimised microsphere formulations designed. entire d...