Gastroesophageal reflux disease is a widespread chronic in which stomach or duodenal contents rise up into the esophagus. Esophageal spasm and achalasia cardia are poorly studied disorders associated with impaired neuromuscular impulse transmission motor discoordination of esophagus, manifested by chest pain dysphagia. The article presents clinical case young patient gastroesophageal history at...

CC This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons. org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. *Correspondence: Ching-Liang Lu, MD Division of Gastroenterology, Department of Medicine...

OBJECTIVE To review the management of gastroesophageal reflux disease (GERD) in adults with esophageal complications (esophagitis, stricture, adenocarcinoma, or Barrett metaplasia) or extraesophageal complications (otolaryngological manifestations and asthma). DATA SOURCES Peer-reviewed publications located via MEDLINE or cross-citation. STUDY SELECTION Emphasis was placed on new developmen...

Treatment of gastroesophageal reflux disease in the United States today is binary, with the majority of patients with gastroesophageal reflux disease being treated with antisecre-tory medications and a minority of patients, typically those with volume regurgitation, undergoing Nissen fundoplication. However, there has been increasing dissatisfaction with proton pump inhibitor therapy among a si...

OBJECTIVE To systematically review the literature evaluating the diagnostic accuracy of commonly used diagnostic tests over conventional history taking and physical examination in children ≤ 18 months and >18 months suspected of gastroesophageal reflux disease (GERD). STUDY DESIGN We searched Medline, Embase, and the Cochrane database for studies assessing the diagnostic accuracy of pH-metry,...

Gastroesophageal reflux disease (GERD) is a chronic disorder and the most common disease that affects the esophagus. A population-based study estimated that 20% of the U.S. adult population experiences GERDrelated symptoms at least once a week [1]. GERD can lead to esophageal mucosal injury in a subset of patients as well as bothersome symptoms, such as heartburn and acid regurgitation, which m...

BACKGROUND/AIMS Impedance-pH monitoring allows detailed characterization of gastroesophageal reflux and esophageal activity associated with reflux. We assessed the characteristics of nocturnal reflux and esophageal activity preceding and following reflux. METHODS Impedance-pH tracings from 11 healthy subjects and 76 patients with gastroesophageal reflux disease off acid-suppressive therapy we...

Pediatric sinus surgery is indicated in patients with rhinosinusitis that does not respond medical therapy after controlling of predisposing factors such as allergic rhinitis, adenoiditis, environmental irritants, and gastroesophageal reflux. Orbital and intracranial extensions from rhinosinusitis requires aggressive medical management and expedient surgical intervention. There is an armamentar...

The mechanical force relationships that distinguish normal from chronic reflux at sphincter opening are poorly understood and difficult to measure in vivo. Our aim was to apply physics-based computer simulations to determine mechanical pathogenesis of gastroesophageal reflux. A mathematical model of the gastroesophageal segment (GES) was developed, incorporating the primary anatomical and physi...