Abstract Bispecific antibodies (bsAbs) are therapeutically promising due to their ability bind two different antigens. However, the bsAb byproducts and impurities, including mispaired homodimers, half-antibodies, light chain mispairings, antibody fragments high levels of molecular weight (HMW) species, all pose unique challenges downstream processing. Here, using knob-into-hole (KiH) constructs...

ÖZET Amaç: Kompozit malzemelerin sıklıkla yapısında yer alan BIS-GMA, polimerizasyondan sonra reaksiyona girmeden kalabilmektedir. Artık monomerlerin bilinen zararlı etkileri nedeniyle, dental malzemelerden salınan monomer miktarlarının belirlenmesi çok önemlidir. Mevcut çalışmanın amacı, kompozit rezin, akışkan ve bulk fill materyallerden BIS-GMA değerlendirilmesidir. Gereç yöntemler: Toplamda...

Antibiotic-loaded bone cement (ALBC) is widely used in orthopaedic surgery for both prevention and treatment of infection. Little is known about the effect of different brand combinations of antibiotic and bone cement on the elution profile and mechanical strength of ALBC. Standardized specimens that consisted of one of the 4 brands of bone cement and one of the 3 brands of vancomycin were fash...

The antimicrobial properties and the elution characteristics of gentamicin-vancomycin-loaded hip spacers were studied in vivo and in vitro. Vancomycin elution was greater than gentamicin elution. The antibiotic concentrations in vivo were less than those in vitro. Not dependent on implantation duration, growth inhibition by spacers in vitro was observed for 2 weeks. The reason for protracted wo...

The efficiency of poliovirus elution from fiber glass cartridge filters (K27), epoxy-fiber glass-asbestos filters (M780), and pleated cartridge filters was assessed by using 3% beef extract (pH 9.0) or 0.1 M glycine (pH 11.5). Poliovirus type I, strain LSc, was seeded into 20- to 25-gallon (ca. 75.6- to 95.6-liter) samples of treated sewage effluent and concentrated by using a filter adsorption...