This project deals with the modelling, control and simulation of a micro electro-mechanical actuator for micromechatronical tweezers in DNA-manipulation processes. I. THE MICRO-MECHATRONICAL PROCESS The manipulation of biological molecules by using micromechanical and optical devices such as: magnetic tweezers [1], [2], optical tweezers [3], AFM cantilevers [4] and microfibers [5], [6], are now...

DNA polymerases are an essential class of enzymes or molecular motors that catalyze processive syntheses during replications. A critical issue for is their mechanism replication. We have proposed a model chemomechanical coupling before, based on which the predicted results been provided about dependence replication velocity upon external force Klenow fragment polymerase I. Here, we performed si...

In this article, we describe the process of binding riboflavin to a simple tetradents ligand substituted in α- position from TPAs types, by reacting bromotetraacetate with TPA one pyridine rings nitrile group and two other halogen atoms. This type ligands showed very important properties for activation transfer oxygen substrate presence iron salt. After were obtained, was reduced an amine where...

OBJECTIVE To evaluate three commercially available tick removal tools against medium-tipped nontissue tweezers. METHODS We evaluated three commercially available tick removal tools against medium-tipped tweezers. Three inexperienced users randomly removed attached American dog ticks (Dermacentor variabilis Say) and lone star ticks (Amblyomma americanum L.) from laboratory rabbits in a univers...

Scattering forces in focused light beams push away metallic particles. Thus, trapping metallic particles with conventional optical tweezers, especially those of Mie particle size, is difficult. Here we investigate a mechanism by which metallic particles are attracted and trapped by plasmonic tweezers when surface plasmons are excited and focused by a radially polarized beam in a high-numerical-...

Over the last decade, single-molecule techniques have proven their wide applicability in the study of processive motor proteins and other enzymes, yielding insight into their kinetics and mechanochemistry. In the context of force spectroscopy of protein–nucleic acid interactions, optical tweezers, magnetic tweezers, and atomic force microscopy have made important contributions. Advantages of ma...

* Author for correspondence ABSTRACT The optical tweezers instrument is a unique tool for directed assembly of nanocomponents. In order to function as a viable nanomanufacturing tool, a software architecture is needed to run the optical tweezers hardware, provide an effective user interface, and allow automated operation. A flexible software system framework is described to utilize the optical ...

Optical tweezers were ®rst realized 15 years ago by Arthur Ashkin and co-workers at the Bell Telephone Laboratories. Since that time there has been a steady stream of developments and applications , particularly in the biologica l ®eld. In the last 5 years the ̄ow of work using optical tweezers has increased signi®cantly, and it seems as if they are set to become a mainstream tool within biologi...