نتایج جستجو برای: molecular clock
تعداد نتایج: 666755 فیلتر نتایج به سال:
The hormone leptin is a regulator of bone remodeling, a homeostatic function maintaining bone mass constant. Mice lacking molecular-clock components (Per and Cry), or lacking Per genes in osteoblasts, display high bone mass, suggesting that bone remodeling may also be subject to circadian regulation. Moreover, Per-deficient mice experience a paradoxical increase in bone mass following leptin in...
Daily oscillations in physiology and behavior are regulated by a brain clock located in the suprachiasmatic nucleus (SCN). Individual cells within this nucleus contain an autonomous molecular clock. Recent discoveries that make use of new molecular and genetic data and tools highlight the conclusion that the SCN is a heterogeneous network of functionally and phenotypically differentiated cells....
In the past few years, several molecular components of the circadian clock have been identified in various organisms. Little by little, researchers have worked out some relationships between metabolism and the circadian clock. Nowadays, due to irregular lifestyle, people suffer from a variety of disorders linked to metabolism, especially obesity, but also cancer, sleep and mental disorders. Acq...
The molecular machinery that governs circadian rhythmicity comprises proteins whose interplay generates time-specific transcription of clock genes. The role of chromatin remodeling in a physiological setting such as the circadian clock is yet unclear. We show that the protein CLOCK, a central component of the circadian pacemaker, has histone acetyltransferase (HAT) activity. CLOCK shares homolo...
Circadian rhythms are autoregulatory, endogenous rhythms with a period of approximately 24 h. A wide variety of physiological and molecular processes are regulated by the circadian clock in organisms ranging from bacteria to humans. Phosphorylation of clock proteins plays a critical role in generating proper circadian rhythms. Casein Kinase2 (CK2) is an evolutionarily conserved serine/threonine...
Altered functioning of the biological clock is involved in cancer onset and progression. MicroRNAs (miRNAs) interact with the clock genes modulating the function of genetically encoded molecular clockworks. Collaborative interactions may take place within the coding-noncoding RNA regulatory networks. We aimed to evaluate the cross-talk among miRNAs and clock genes in colorectal cancer (CRC). We...
Vallone, Daniela, Elena Frigato, Cristiano Vernesi, Augusto Foà, Nicholas S. Foulkes, and Cristiano Bertolucci. Hypothermia modulates circadian clock gene expression in lizard peripheral tissues.Am J Physiol Regul Integr Comp Physiol 292: R160–R166, 2007. First published June 29, 2006; doi:10.1152/ajpregu.00370.2006.— The molecular mechanisms whereby the circadian clock responds to temperature ...
Circadian rhythms are autoregulatory, endogenous rhythms with a period of approximately 24 h. A wide variety of physiological and molecular processes are regulated by the circadian clock in organisms ranging from bacteria to humans. Phosphorylation of clock proteins plays a critical role in generating proper circadian rhythms. Casein Kinase2 (CK2) is an evolutionarily conserved serine/threonine...
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