OBJECTIVES Several investigations have revealed that caspase-14 is responsible for the epidermal differentiation and cornification, as well as the regulation of moisturizing effect. However, the precise regulation mechanism is still not clear. This study was aimed to investigate the expression of caspase-14 in filaggrin-deficient normal human epidermal keratinocytes (NHEKs) and to explore the p...

Panthenol is the alcohol analogue of panthothenic acid, known as vitamin B5, which is required for the biosynthesis of coenzyme A in cells. This compound exists as two stereoisomers, D-pathenol and L-panthenol, only the former being biologically active (1). It is a common ingredient in pharmaceutical products, for example in topical treatments for rhinitis, conjunctivitis, sunburn, and wounds, ...

risk of developing melanoma, even after skin cancer risk factors including skin type are controlled for. Hispanics also are less knowledgeable about melanoma, less likely to perform self-examinations, and often unaware of the clinical signs of skin cancer; they have worse outcomes. The worse outcomes are to result from issues of health care delivery, but the possibility exists that melanomas in...