Class V myosins play a pivotal role in organelle distribution. In the budding yeast, Myo2p, a class V myosin, is essential for mitochondrial distribution. We identified MMR1 as a high-dose suppressor of the myo2 mitochondrial defect and that Mmr1p resides restrictively on the bud-localizing mitochondria and forms a complex with Myo2p tail. Mmr1p loss delayed mitochondrial transfer to buds and c...

Previous studies indicate that replicative lifespan in daughter cells of Sacchraromyces cerevisiae depends on the preferential inheritance of young, high-functioning mitochondria. We report here that mitochondria are functionally segregated even within single mother cells in S. cerevisiae. A high-functioning population of mitochondria accumulates at the tip of the mother cell distal to the bud....

Microbial fuel cells (MFCs) are processes used for simultanuous bioenergy capturing and waste treatment. In this study, a model for MFCs based upon a conduction mechanism for electron transfer is proposed, which integrates substrate utilization, current production and conduction and  microbial distribution and growth in batch flow mode. The outputs of the model and that of a mediator based mode...

Discrimination between disomic and tetrasomic inheritance aids in determining whether tetraploids originated by allotetraploidy or autotetraploidy, respectively. Past assessments of inheritance in tetraploids have used analyses whereby each inheritance hypothesis is tested independently. I present a Bayesian analysis that is appropriate for discriminating among several inheritance hypotheses an...

We study a version of the Tangled Nature model of evolutionary ecology redefined in a phenotype space where mutants have properties correlated to their parents. The model has individual-based dynamics whilst incorporating species scale competitive constraints and a system scale resource constraint. Multiple species arise that coexist in a species interaction network with evolving global propert...

Yeast cells with the mdm10 mutation possess giant spherical mitochondria and are defective for mitochondrial inheritance. The giant mitochondria display classical features of mitochondrial ultrastructure, yet they appear incapable of movement or division. Genetic analysis indicated that the mutant phenotypes resulted from a single nuclear mutation, and the isolated MDM10 gene restored wild-type...

This paper concerns the kinetic limit of the Dirac equation with random electromagnetic field. We give a detailed mathematical analysis of the radiative transport limit for the phase space energy density of solutions to the Dirac equation. Our derivation is based on a martingale method and a perturbed test function expansion. This requires the electromagnetic field to be a space-time random fie...

As is the case for all interesting questions in economics, the only good answer to this problem is “It depends.”. It is fairly easy to see how this works on intuitive grounds. Thomas’s offer in Zürich does not pay him enough to live exactly the lifestyle that he enjoys in Ann Arbor, as he would need a 60% raise to cover rent and consumption. The elasticity of substitution is key. If it is high,...

198 lactic acid bacteria (lab) were isolated from iranian milk samples. almost all isolatedlab showed inhibitory activity towards e. coli and s. aureus as gram negative and grampositive indicators, respectively. no role was observed for hydrogen peroxide in the activity ofall isolated strains while organic acids proved a prominent role in all detected inhibitoryactivities. within isolated lab, ...