A chondrosarcoma is a common tumor of the soft tissue and bone that has high propensity to metastasize distant organs. Nerve growth factor (NGF) capable promoting progression metastasis several different types tumors although effects NGF in are not confirmed. Here, we found levels matrix metalloproteinase-2 (MMP-2) correlated with stage patients chondrosarcoma. facilitated MMP-2-dependent cellu...

Purpose: Although osteosarcoma is the most common primary malignant bone tumor among adolescents and young adults, molecular mechanisms underlying development of cancer are not fully elucidated. Cyclophosphamide (CYC) an alkylating antineoplastic agent widely used in treatment regimens various cancers chronic inflammatory diseases. The aim this study to reveal effect CYC on Saos-2 cells at leve...

Pathogenic memory T cells are implicated in the local relapse of allergic contact dermatitis (ACD), vitiligo and psoriasis. Here we investigate how resident initiate relapses response to allergen Methylisothiazolinone (MI). MI–related ACD was sampled two months years after resolution disease. were activated skin explants with MI or pan T-cell agonist OKT-3. Epidermis analysed by RNAseq, Nanostr...

Background: Rosmarinic acid (RA) is a natural phenolic compound that acts as Fyn inhibitor by 53 homology modeling of the human structure. Therefore, apoptosis mechanism related to NF-κB signaling pathway induced RA in HepG2 was investigated. Methods: The cell growth, apoptosis, and proliferation regulated various concentrations were studied. proteins expression MMP-2, MMP-9, PI3K, AKT, NF-κB, ...

Background: During the first trimester of pregnancy the uterine spiral arteries that supply blood to the placenta are remodelled, creating heavily dilated conduits lacking maternal vasomotor control. To effect permanent vasodilatation, the internal elastic lamina and medial elastic fibres must be degraded. Failure of remodelling is a key characteristic of the pathological placenta and is though...

Carbon dioxide flooding is considered to be one of the most effective enhanced oil recovery methods for the light oil reservoirs. Depending on the operating pressure, the process might be miscible or immiscible. Minimum miscibility pressure (MMP) is the most important parameter for assessing the applicability of any miscible gas flood for an oil reservoir. The miscibility condition is determine...

Objective Objective: Gelatinases degrade extracellular matrix (ECM) components to make physiological remodeling and contribute to pathological tissue destruction in endometriosis. It is known that gelatinases’ function is resistant to suppression by progesterone in endometriosis. The ability of progesterone to impact gene expression depends on the progesterone receptor-A/-B (PR-A/PR-B) ratio. A...

 Cerebrovascular disease is one of the leading causes of death in the world, and about one-fourth of cerebrovascular deaths are due to ruptured cerebral aneurysms (CA). Hence it is important to find a way to reduce aneurysm formation and its subsequent morbidity and mortality. Proteolytic activity capable of lysing gelatin has been shown to be increased in aneurysm tissue and expressio...

Pleomorphic adenoma (PA) is the most common neoplasm of salivary glands and consists epithelial mesenchymal components. Although a benign lesion, it harbors potential for recurrence malignant transformation. Also, due to its histological diversity unpredictive behavior PA can represent both diagnostic therapeutic challenge. Matrix metalloproteinases (MMPs) are well known modifiers extracellular...