By using different evaluation strategies, we systemically evaluated the performance of Molecular Mechanics/Generalized Born Surface Area (MM/GBSA) and Molecular Mechanics/Poisson-Boltzmann Surface Area (MM/PBSA) methodologies based on more than 1800 protein-ligand crystal structures in the PDBbind database. The results can be summarized as follows: (1) for the one-protein-family/one-binding-lig...

One can build an operatorial model for freeness by considering either the right-handed or left-handed representation of algebras operators acting on free product underlying pointed Hilbert spaces. Considering both at same time, that is, computing distributions in algebra generated left- and representations, led Voiculescu 2013 to define study bifreeness and, sequel, triggered development extens...

This memo reviews the requirements for using the ALMA array as a part of a global VLBI array at millimeter wavelengths. ALMA can be outfitted for VLBI at modest cost and should be planned with this capability in mind, as it may be more difficult to retrofit at a later date. The essential features required in the ALMA design are discussed.

Your use of the JSTOR archive indicates your acceptance of JSTOR's Terms and Conditions of Use, available at http://www.jstor.org/about/terms.html. JSTOR's Terms and Conditions of Use provides, in part, that unless you have obtained prior permission, you may not download an entire issue of a journal or multiple copies of articles, and you may use content in the JSTOR archive only for your perso...

With the rapid development of computational techniques and hardware, more rigorous and precise theoretical models have been used to predict the binding affinities of a large number of small molecules to biomolecules. By employing continuum solvation models, the MM/GBSA and MM/PBSA methodologies achieve a good balance between low computational cost and reasonable prediction accuracy. In this stu...