BACKGROUND Diffusion tensor imaging (DTI) characterizes multiple sclerosis (MS) tissue injury, although it has remained unproven whether DTI changes in disease have functional consequences. The medial longitudinal fasciculus (MLF) is a key brainstem pathway for ocular adduction and is commonly injured in patients with MS, typically resulting in internuclear ophthalmoparesis. OBJECTIVE To vali...

1 Departamento de Lenguajes y Sistemas Informáticos e Ingeniería de Software Universidad Politécnica de Madrid Campus de Montegancedo. 28660. Boadilla del Monte. Madrid. España [email protected] 2 Departamento de Procesos y Sistemas Universidad Simón Bolívar, Edf. Matemáticas y Sistemas. Caracas. Venezuela. [email protected] 3 Departamento de Ingeniería del Software e Inteligencia Artificial. Univ...

The effects of global climate change and increasing environmental awareness have led to an increase in the significance projects and, accordingly, finance green bonds. Despite significance, fact that price forecasting studies on bonds are extremely scarce has been main motivation this study. aim paper is forecast corporate bond prices with Artificial Neural Network model determine predictor by ...

In this paper, we discuss the efficiency of various numerical methods for the inverse design of the Burgers equation, both in the viscous and in the inviscid case, in long time-horizons. Roughly, the problem consists in, given a final desired target, to identify the initial datum that leads to it along the Burgers dynamics. This constitutes an ill-posed backward problem. We highlight the import...

A 64-year-old woman, diabetic and hypertensive, presented with sudden onset painless diplopia and alteration of consciousness. She was drowsy with neurological examination revealing exotropia of both eyes in primary position with bilateral internuclear ophthalmoplegia on attempted horizontal gaze (Figure 1a). Pupils were normal bilaterally. Convergence, vertical saccades, pursuits and vestibula...

BACKGROUND The vertical vestibulo-ocular reflex (VOR) may be impaired in internuclear ophthalmoplegia (INO) as the medial longitudinal fasciculus (MLF) conveys VOR-signals from the vertical semicircular canals. It has been proposed that signals from the contralesional posterior semicircular canal (PSC) are exclusively transmitted through the MLF, while for the contralesional anterior canal othe...

PURPOSE Lipofuscin (LF) and melanolipofuscin (MLF) of the retinal pigment epithelium (RPE) are the principal sources of autofluorescence (AF) signals in clinical fundus-AF imaging. Few details about the subcellular distribution of AF organelles in AMD are available. We describe the impact of aging and AMD on RPE morphology revealed by the distribution of AF LF/MLF granules and actin cytoskeleto...

Oenococcus oeni is the main microorganism that undergoes malolactic fermentation (MLF) in winemaking industry due to its excellent adaptability harsh wine environments. The start of MLF often delayed or even fails, and low pH appears be a crucial parameter. To study function trxA gene acid stress, plasmid containing O. SD-2a was heterologously expressed Lactiplantibacillus plantarum WCFS1. reco...

in order to reduce both the weight of vehicles and the damage of occupants in a crash event simultaneously, it is necessary to perform a multi-objective optimization of the automotive energy absorbing components. in this paper, axial impact crushing behavior of the aluminum foam-filled thin-walled tubes are studied by the finite element method using commercial software abaqus. comparison of the...

We describe three results in this thesis. We first present a heuristic improvement for a shortest path problem, which we termed single-source many-targets shortest path problem. In this problem, we need to compute a shortest path from a source node to a node that belongs to a designated target set. Dijkstra’s algorithm can be used to solve this problem. We are interested in the single-source ma...