BACKGROUND Atypical antipsychotics are increasingly used for treatment of mental illnesses like schizophrenia and bipolar disorder, and considered to have fewer extrapyramidal effects than older antipsychotics. METHODS We examined efficacy in randomised trials of bipolar disorder where the presenting episode was either depression, or manic/mixed, comparing atypical antipsychotic with placebo ...

1154 Emerging Infectious Diseases • www.cdc.gov/eid • Vol. 11, No. 7, July 2005 PanBio Pty. Ltd., Brisbane, Australia). The same acute-phase serum was tested for flavivirus RNA by seminested reverse transcription–polymerase chain reaction (RT-PCR) by using flavivirus consensus primers PF1S and PF2R as previously described (1) in conjunction with the sense primer PF3S (GCIATHTGGTAYATGTGGYT). Att...

BACKGROUND Much remains unknown about the phenomenology of bipolar I disorder. AIMS To determine the type of bipolar I mood episodes that occur over time, and their relative frequency. METHOD A total of 219 individuals with Research Diagnostic Criteria bipolar I disorder were prospectively followed for up to 25 years (median 20 years). Psychopathology was assessed with the Longitudinal Inte...

This case report describes an episode of acute ataxia, tremor, vertical nystagmus and progressive weakness in a mixed breed dog treated with high doses of metronidazole. Complete blood cell count, serum biochemistry, coagulation profile, blood pressure measurement, urinalysis, computed tomography of the brain and cerebrospinal fluid examination were unremarkable. Metronidazole had been administ...

This paper presents a language-model training method for improving automatic transcription of online spoken contents. Unlike previously studied LVCSR tasks such as broadcast news and lectures, large-sized task-specific corpora for training language models cannot be prepared and used in recognition because of the diversity of topics, vocabularies, and speaking styles. To overcome difficulties in...

Introduction. Mixed states represent a frequent presentation of bipolar disorder, associated with higher resistance to psychopharmacology. Limited evidence supports the use of ECT in these patients. We aim to report our experience on treating bipolar mixed states with ECT. Methods. Retrospective data were collected from all bipolar patients submitted to acute ECT treatment, between June 2006 an...

Knowledge-based learning environments provide an ideal testbed for developing and evaluating computational models of mixed initiative interaction. In each problem-solving episode, learners incrementally develop solutions for problems posed by the environment. To maximize learning e ectiveness and learning e ciency, we have been developing animated pedagogical agents that dynamically provide exp...

OBJECTIVE Mixed (subsyndromal hypomanic) features are prevalent in patients with bipolar depression and are associated with more severe and complex illness, including increased risk for suicide attempts, higher switch to mania during antidepressant therapy, and a higher rate of recurrence. The aim of this post hoc analysis was to evaluate the efficacy and safety of lurasidone in the treatment o...