objective(s): as mitochondrial oxidative stress is probably entailed in atp production, a candidate modifier factor for the long qt syndrome (lqts) could be mitochondrial dna (mtdna). it has been notified that ion channels' activities in cardiomyocytes are sensitive to the atp level. materials and methods: the sample of the research was an iranian family with lqts for mutations by pcr-sscp...

considerable evidence suggests that mitochondrial dysfunction contributes to the toxicity of uranyl acetate (ua), a soluble salt of depleted uranium (du). we examined the ability of the two antioxidants, beta-glucan and butylated hydroxyl toluene (bht), to prevent ua-induced mitochondrial dysfunction using rat-isolated kidney mitochondria. beta-glucan (150 nm) and bht (20 nm) attenuated ua-indu...

Downregulation of mitochondrial function in adipose tissue is considered as one important driver for the development obesity-associated metabolic disorders. Inorganic pyrophosphatase 1 (PPA1) an enzyme that catalyzes hydrolysis inorganic pyrophosphate to phosphate and required anabolism take place cells. Although alteration PPA1 has been related some diseases, importance syndromes never discuss...

PSYCHIATRIC ANNALS • Vol. 44, No. 11, 2014 495 ABSTRACT Monoamine oxidase (MAO) isoenzymes A and B are mitochondrial-bound proteins that catalyze the oxidative deamination of dietary amines and monoamine transmitters. Others include: serotonin, epinephrine, 2-phenylethylamine, and dopamine. MAOs can potentially modulate all the processes involving bioactive amines, including regulation of mood,...

Monosodium glutamate (MSG) is a flavor enhancer, largely used in the food industry and it was reported to have excitotoxic effects. Higher amounts of MSG consumption have been related with increased risk of many diseases, including Chinese restaurant syndrome and metabolic syndromes in human. This study investigated the protective effects of N-acetylcysteine (NAC) on MSG-induced cytotoxicity in...

Fanconi anemia (FA) is known as an inherited bone marrow failure syndrome associated with cancer predisposition and susceptibility to a number of DNA damaging stimuli, along with a number of clinical features such as upper limb malformations, increased diabetes incidence and typical anomalies in skin pigmentation. The proteins encoded by FA-defective genes (FANC proteins) display well-establish...