Recurrent miscarriage affects 1% of all couples attempting pregnancy. Immunological factors are postulated to play a role in the aetiology of recurrent miscarriage because the fetus and placenta are immunologically different from the mother. In particular, altered expression of the, non-classical, class I histocompatibility leukocyte antigen (HLA) molecules has been postulated to play a role in...

Activated protein C (APC) resistance, both in its congenital form, due to the factor V Leiden mutation, and in its acquired form, are important risk factors for systemic venous thrombosis. In view of the suspected thrombotic aetiology of some cases of recurrent miscarriage, the prevalence of APC resistance was determined among 1111 consecutive Caucasian women with a history of either recurrent ...

OBJECTIVE To determine whether a history of miscarriage is related to birth experience and/or maternal fear of an adverse birth outcome for self or infant during a subsequent delivery. DESIGN Secondary analysis of a prospective cohort study, the First Baby Study. SAMPLE Women age 18 to 35 who were expecting to deliver their first live-born infants in Pennsylvania between January 2009 and Ap...

OBJECTIVE To evaluate anti-Mullerian hormone, basal follicle stimulating hormone, luteinizing hormone, estradiol, and female age in women with recurrent miscarriage and to compare women with explained and idiopathic recurrent miscarriage. DESIGN Retrospective cohort study. SETTING University hospital, tertiary care center. PATIENTS Women with recurrent miscarriage (78 explained, 66 idiopa...

BACKGROUND Miscarriage is the most common negative outcome of pregnancy, and identification of modifiable risk factors is potentially of great importance for public health. Low vitamin D concentrations in pregnancy are widespread worldwide, and vitamin D deficiency is implicated in immune cell regulation at the feto-maternal interface and several diseases of pregnancy. OBJECTIVE We investigat...

STUDY QUESTION Is there a relationship between ovarian reserve, quantified as ovarian response to stimulation, and miscarriage rate following IVF treatment? SUMMARY ANSWER There is a strong association between the number of oocytes retrieved and miscarriage rate following IVF treatment, with the miscarriage rate decreasing with an increasing number of oocytes and then levelling off: poor resp...

ectopic pregnancy (ep) and miscarriage are important differential diagnosis of first trimester vaginal bleeding. in first trimester, serum progesterone value can be 5-20 ng/ml in ep and miscarriage. since delay in diagnosis of ep could have high mortality and morbidity, the aim of this study was comparison of serum progesterone value in ep and miscarriage in order to differentiate these conditi...

background: adequate serum level of zinc and selenium is required for normal metabolic performance and successful fertility. the present study was conducted to evaluate the association of serum zinc and selenium in early stage of gestation with the incidence of miscarriage in iranian women. materials and methods: one hundred two females were studied in three matched groups. group 1 consisted of...