نتایج جستجو برای: mirna target genes

تعداد نتایج: 793481  

2012
Elisabeth John Anke Wienecke-Baldacchino Maria Liivrand Merja Heinäniemi Carsten Carlberg Lasse Sinkkonen

Peroxisome proliferator-activated receptor γ (PPARγ) is a key transcription factor in mammalian adipogenesis. Genome-wide approaches have identified thousands of PPARγ binding sites in mouse adipocytes and PPARγ upregulates hundreds of protein-coding genes during adipogenesis. However, no microRNA (miRNA) genes have been identified as primary PPARγ-targets. By integration of four separate datas...

2008
Sheng-Da Hsu Chia-Huei Chu Ann-Ping Tsou Shu-Jen Chen Hua-Chien Chen Paul Wei-Che Hsu Yung-Hao Wong Yi-Hsuan Chen Gian-Hung Chen Hsien-Da Huang

MicroRNAs (miRNAs) are small non-coding RNA molecules that can negatively regulate gene expression and thus control numerous cellular mechanisms. This work develops a resource, miRNAMap 2.0, for collecting experimentally verified microRNAs and experimentally verified miRNA target genes in human, mouse, rat and other metazoan genomes. Three computational tools, miRanda, RNAhybrid and TargetScan,...

2014
Elnaz Naderi Mehdi Mostafaei Akram Pourshams Ashraf Mohamadkhani

BACKGROUND MicroRNAs are small RNA molecules that regulate the expression of certain genes through interaction with mRNA targets and are mainly involved in human cancer. This study was conducted to make the network of miRNAs-mRNAs interactions in pancreatic cancer as the fourth leading cause of cancer death. METHODS 56 miRNAs that were exclusively expressed and 1176 genes that were downregula...

2014
Farid E Ahmed

The biogenesis of micro (mi) RNA suggests that nearly 3% of human genes are encoded for micro (mi) RNAs, and computer predictions indicate that more than 30% of protein coding genes in humans are coded by miRNAs through an imperfect binding to the 3’ untranslated region (UTR) of target messenger (m) RNA affecting gene silencing and leading to either transcription repression, or induction of mes...

2011
T.M Witkos E Koscianska W.J Krzyzosiak

microRNAs (miRNAs) are endogenous non-coding RNAs that control gene expression at the posttranscriptional level. These small regulatory molecules play a key role in the majority of biological processes and their expression is also tightly regulated. Both the deregulation of genes controlled by miRNAs and the altered miRNA expression have been linked to many disorders, including cancer, cardiova...

2012
Takaya Saito Pål Sætrom

BACKGROUND MicroRNA (miRNA) target genes tend to have relatively long and conserved 3' untranslated regions (UTRs), but to what degree these characteristics contribute to miRNA targeting is poorly understood. Different high-throughput experiments have, for example, shown that miRNAs preferentially regulate genes with both short and long 3' UTRs and that target site conservation is both importan...

2012
Masafumi Nozawa Sayaka Miura Masatoshi Nei

MicroRNAs (miRNAs) are among the most important regulatory elements of gene expression in animals and plants. However, their origin and evolutionary dynamics have not been studied systematically. In this paper, we identified putative miRNA genes in 11 plant species using the bioinformatic technique and examined their evolutionary changes. Our homology search indicated that no miRNA gene is curr...

Journal: :iranian journal of basic medical sciences 0
shouhua zheng department of general surgery, the first affiliated hospital of zhengzhou university, zhengzhou, henan, 450052 china shuijun zhang department of general surgery, the first affiliated hospital of zhengzhou university, zhengzhou, henan, 450052 china yan song department of general surgery, the first affiliated hospital of zhengzhou university, zhengzhou, henan, 450052 china wenzhi guo department of general surgery, the first affiliated hospital of zhengzhou university, zhengzhou, henan, 450052 china wenlong zhai department of general surgery, the first affiliated hospital of zhengzhou university, zhengzhou, henan, 450052 china xinguang qiu department of general surgery, the first affiliated hospital of zhengzhou university, zhengzhou, henan, 450052 china

objective(s): vascular calcification is one the major characteristics in patients with various types of chronic inflammatory disorders. mirnas have been shown to be involved in many normal biological functions as well as diseases; however, their role in vascular calcification has not received much attention. materials and methods: in the current study, we built a vascular calcification rat mode...

2016
Diana Diaz Sorin Draghici

mirIntegrator is an R package for integrating microRNAs (miRNAs) into signaling pathways to perform pathway analysis using both mRNA and miRNA expressions. Typical pathway analysis methods help to investigate which pathways are relevant to a particular phenotype understudy. The input of these methods are the fold change of mRNA of two different phenotypes (e.g. control versus disease), and a se...

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