نتایج جستجو برای: mirna 7
تعداد نتایج: 663954 فیلتر نتایج به سال:
Adenosine deaminases acting on RNAs (ADARs) convert adenosine residues to inosines in primary microRNA (pri-miRNA) transcripts to alter the structural conformation of these precursors and the subsequent functions of the encoded microRNAs (miRNAs). Here we show that RNA editing by Drosophila ADAR modulates the expression of three co-transcribed miRNAs encoded by the evolutionarily conserved let-...
objective(s): menopause and diabetes obviously increase the risk of cardiovascular disease in women. the aims of the present study were to evaluate the effects of ovariectomy in type 2 diabetes on the histology and expression of mirna-29, mirna-133, igf-1 and bcl-2 genes and bcl-2 protein and caspase 3 activity in the hearts of female rats. materials and methods: forty female wistar rats were d...
زمینه و هدف: سرطان پروستات یکی از شایع‌ترین سرطان‌ها در بین مردان است که بروز آن در بسیاری از کشورها در حال افزایش است. بر اساس مطالعات انجام شده کاهش بیان miRNA-143 در سرطان پروستات گزارش شده است. در این تحقیق با جایگزینی miRNA-143 در سلولهای سرطان پروستات (PC3) از طریق انتقال ژن miRNA-143 توسط وکتور، بیان این میکروRNA را در این سلولها افزایش داده و اثرات این میکروRNA در مهار متاستاز بررسی ...
Background & Aims: Lung cancer is the most common cancer in men and the main cause of male cancer deaths worldwide. Also, it is the second leading cause of cancer deaths in women worldwide. In this study, we replaced miRNA145 in lung cancer cells by vector based miRNA-145, then the level of miRNA expression in these cells increased and we investigated the effects of the miRNA on inhibition of m...
Background: Esophageal Squamous Cell Carcinoma (ESCC) is the seventh most common and lethal malignancy worldwide with a high incidence in Iran. Esophageal cancer has a poor prognosis and low 5-years survival rate. Despite several studies on esophageal cancer, its underlying mechanism remains unclear. Therefore, it is significant to analyze the molecular factors involved in disease for introduci...
Abstract Background Breast cancer is the most frequently diagnosed malignancy among women. However, role of microRNA (miRNA) expression in breast progression not fully understood. In this study we examined predictive interactions between differentially expressed miRNAs and mRNAs cell lines representative common molecular subtypes. Integrative bioinformatics analysis identified miR-193 miR-210 a...
سرطان ریه یکی از علل اصلی مرگ و میر ناشی از سرطان در سطح دنیاست. مطالعات سیتوژنتیکی نشان می دهد که تومورهای ریوی ناهنجاری کروموزومی مختلفی را نشان می دهند که جهش در بازوی کوتاه کروموزوم 3 یکی از موارد شایع می باشد. mirna ها rna های غیر کد کننده تک رشته ای کوچکی هستند که بعنوان تنظیم کننده های بیان ژن در سطح بعد از رونویسی عمل می کنند. mirna ها فرایندهای مهم سلولی همانند تکثیر، تمایز، اپوپتو...
The lethal-7 (let-7) miRNA, known as one of the first founding miRNAs, is present in multiple copies in a genome and has diverse functions in animals. In this study, comparative genomic analysis of let-7 miRNAs members in fish species indicated that let-7 miRNA is a sequence conserved family in fish, while different species have the variable gene copy numbers. Among the ten members including le...
BACKGROUND Mature miRNAs can often be classified into large families, consisting of members with identical seeds (nucleotides 2 through 7 of the mature miRNAs) and highly homologous approximately 21-nucleotide (nt) mature miRNA sequences. However, it is unclear whether members of a miRNA gene family, which encode identical or nearly identical mature miRNAs, are functionally interchangeable in v...
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