Cutaneous leishmaniasis(CL) is referred to a group of diseases because of the varied clinical presentation, ranging from small cutaneous nodule to wide spread mucosal destruction. The nose is rarely involved by CL in even in endemic region. In this report we describe a rare rhinophymatous presentation of CL from a non-endemic region which was diagnosed by fine needle sampling and treated with M...

Visceral leishmaniasis (VL) or Kala-azar is the most severe form of leishmaniasis and is uniformly fatal, if untreated. An estimated 500,000 new cases occur per year, 90% of which occur in the endemic areas of India, Bangladesh, Sudan Nepal and Brazil. More than 100,000 cases of VL occur in India alone every year and the state of Bihar accounts for more than 90% of these. Over the years new the...

Leishmania infantum is an etiological agent of the life-threatening visceral form of leishmaniasis. Liposomal amphotericin B (AmB) followed by a short administration of miltefosine (MF) is a drug combination effective for treating visceral leishmaniasis in endemic regions of India. Resistance to MF can be due to point mutations in the miltefosine transporter (MT). Here we show that mutations in...

Combination therapy for the treatment of visceral leishmaniasis has increasingly been advocated as a way to increase treatment efficacy and tolerance, to reduce treatment duration and cost, and to limit the emergence of drug resistance. In the present work, we have adopted a rational approach, which can modulate the immune response to overcome the negative control systems and to boost the posit...

We studied the stress proteins induced in protozoa Leishmania donovani after treatment with edelfosine, miltefosine and ilmofosine. We studied the morphological and structural modifications caused in the promastigote forms of the parasite after treatment with the three alkyl-lysophospholipids (ALPs). A resistant strain of L. donovani to miltefosine was obtained and the morphological modificatio...

cutaneous leishmaniasis(cl) is referred to a group of diseases because of the varied clinical presentation, ranging from small cutaneous nodule to wide spread mucosal destruction. the nose is rarely involved by cl in even in endemic region. in this report we describe a rare rhinophymatous presentation of cl from a non-endemic region which was diagnosed by fine needle sampling and treated with m...

Primary amebic meningoencephalitis (PAM) is a fulminant central nervous system infection caused by the thermophilic free-living ameba Naegleria fowleri. Few survivals have been documented and adequate treatment is lacking. We report 2 PAM cases, 1 fatal and 1 surviving, treated with the novel antiparasitic agent miltefosine.

Granulomatous amoebic encephalitis (GAE) due to Acanthamoeba is almost a uniformly fatal infection in immune-compromised hosts despite multidrug combination therapy. We report a case of GAE in a female who received a deceased donor kidney graft. She was treated with a combination of miltefosine, pentamidine, sulfadiazine, fluconazole, flucytosine, and azithromycin.