CONTEXT Management of acne vulgaris by nondermatologists is increasing. Current understanding of the different presentations of acne allows for individualized treatments and improved outcomes. OBJECTIVE To review the best evidence available for individualized treatment of acne. DATA SOURCES Search of MEDLINE, EMBASE, and the Cochrane database to search for all English-language articles on a...

Dapsone 7.5% gel (Aczone®) is indicated for the once-daily topical treatment of acne vulgaris in patients aged ≥12 years. Dapsone is a sulfone antibacterial with anti-inflammatory actions, which are thought to be largely responsible for its efficacy in treating acne vulgaris. In two phase III trials of 12 weeks' duration in patients aged ≥12 years with moderate acne vulgaris, once-daily dapsone...

Evidence • Three RCTs compared conventional with low dosing. -For 24 weeks, 60 patients with moderate acne used low (0.25 to 0.4 mg/kg daily) or conventional doses (0.5 to 0.7 mg/kg daily).1 The low-dose group showed equivalent efficacy (acne grading and lesion counts); increased patient satisfaction (76% very satisfied vs 31%); and a higher (non-significant) 1-year relapse rate (18% vs 13%). -...

BACKGROUND Over the past decade, lasers and light-based systems have become a common modality to treat a wide variety of skin-related conditions, including acne vulgaris. In spite of the various oral and topical treatments available for the treatment of acne, many patients fail to respond adequately or may develop side effects. Therefore, there is a growing demand by patients for a fast, safe, ...

BACKGROUND The efficacy and safety of clindamycin phosphate 1.2%/tretinoin 0.025% (Clin-RA) were evaluated in three 12-week randomised studies. OBJECTIVES To perform a pooled analysis of data from these studies to evaluate Clin-RA's efficacy and safety in a larger overall population, in subgroups of adolescents and according to acne severity. MATERIALS & METHODS 4550 patients were randomise...

BACKGROUND AND DESIGN Acne vulgaris frequently occurs in the second decade of life. The pathogenesis of the disease is multifactorial and in the present study, we aimed to investigate the role of reactive oxygen species in the inflammation of acne by determining the activities of myeloperoxidase (MPO) and superoxide dismutase (SOD) in polymorphonuclear leukocytes (PMN). MATERIALS AND METHODS ...

Eight hundred and seventy one girls (439 black and 432 white) from public and parochial schools, representing diverse socio-economic groups, were recruited for this study, as a part of the National Heart, Lung, and Blood Institute's Growth and Health Study from 1987 through 1991. The annual examinations included age, date of onset of menarche, severity of acne and anthropometric measurements. S...

Introduction: Acne vulgaris is a pilosebaceous unit disorder which mostly seen in adolescents and adults with approximately 85% occurs at the age of 12-25 years. Methods: The purpose this study to know comparison between chemical peeling therapy 35% glycolic acids (GA) 30% mandelic (MA) reduce severity acne vulgaris. A total 30 medical students suffering from mild severe were involved study. pa...

The diagnosis and management of four cases of dermatological disorders, most of which are related to the endocrine disorder of androgen excess, are presented. Combined oral contraceptives (COCs) may be useful when well-tolerated hormonal therapy and/or when contraception is required. A female patient with androgenetic alopecia or female pattern balding, without underlying hyperandrogenism, was ...

BACKGROUND A rising number of laser- or light-based therapies are addressing the need for effective acne treatments with minimal downtime. OBJECTIVE The purpose of this study is to evaluate an intense pulsed light (IPL) equipped with a 530- to 750-nm filter for inflammatory acne treatment. PATIENTS AND METHODS Thirty female patients (mean age, 25.7 years) with mild-to-moderate acne were enr...