Diagnosis of neuromuscular disease by the study of motor endplate structure in the light and electron microscopes is probably one of the most specialized examinations in the field of neuropathology. The classical means of staining endplates using gold, silver or methylene blue are described as well as more modern techniques suitable for light microscopy. Specific abnormalities in patterns of te...

The authors present the case of a 55-year-old woman with a nonfunctioning intrapericardial paraganglioma. The tumor was incidentally found during transthoracic echocardiography that was performed because an enlarged cardiac silhouette had been noted on a chest x-ray. Transesophageal echocardiography further elucidated that the left circumflex coronary artery branched and traversed into the intr...

The spores of Henneguya salminicola, a common tissue parasite of salmonid fishes in the northern hemisphere, were observed in stool specimens from two different patients with diarrhea. The spores' superficial resemblance to human spermatozoa resulted, in one instance, in an incorrect report, leading to suspicion of sexual abuse. H. salminicola spores and human spermatozoa can be differentiated ...

Two patients with Leber's hereditary optic neuropathy underwent morphological and biochemical investigations of muscle biopsy samples from the biceps brachii. Although clinically there was no muscle weakness or atrophy, specific histochemical and electron microscopic examinations showed mild but distinct myopathic changes, including abnormal oxidative enzyme activities, aggregates of enlarged m...

We described a Saudi patient infected with Diphyllobothrium latum D. latum. A 38-year-old male presented, complaining of passing worms. He had a history of recent travel to Europe and South East Asia. Stools examination revealed typical D. latum eggs. He was treated with praziquantel followed by saline purge, after which he discharged an intact tapeworm. Macroscopic and microscopic examinations...

The existence of jaundice induced by hyperemesis gravidarum is controversial. We report the case of a woman who suffered from three episodes of jaundice during the first trimester of three consecutive pregnancies, a few days after the onset of hyperemesis gravidarum. Jaundice was caused by conjugated hyperbilirubinaemia. Serum alanine aminotransferase activity was increased and scarce necrotic ...

Pathology is a bridging discipline that involves both basic and clinical biomedical sciences. In this context, it includes both descriptive and mechanistic approaches, with the final goals of further understanding the anatomic and functional changes and underlying molecular events involved in disease-related processes. Pathology studies mainly comprise macroscopic and microscopic examinations, ...

In the course of experiments involving centrifugation of fresh postprandial human serum diluted with isotonic sucrose, an unexpected phenomenon was noted; the usual opaque fat layer at the surface was missing, and a white pellet was deposited at the bottom of the tube. Microscopic and chemical examinations revealed the deposit to be composed of chylomicrons. Further study of this phenomenon dem...

Background: Zinc oxide (ZnO) nanoparticles are used for various industrial and domestic purposes and its release into the environment leads to the adverse effects among humans. This study aimed to evaluate the effect of rat exposure to ZnO nanoparticles on the histopathology of the liver and pancreas tissues, and serum oxidative stress parameters. Methods: Eighty female adult Wistar rats were ...

Some 800 soil and rotten wood samples were collected from Gilan, Mazandaran and GolestanProvinces in the north of Iran. By using selective and general media, 217 Trichoderma isolates were obtained belonging to sections Longibrachiatum (69 isolates) and Pachybasium (148 isolates), respectively. Pure cultures were obtained by single conidium and single chain methods. Colony features were recorded...