Background: Considering the anti-oxidant properties of Pistacia atlantica and lack of data regarding its efficacy in the treatment of ulcerative colitis, this study aims at investigating the effect of the Pistacia atlantica fruit extract in treating experimentally induced colitis in a rat model.Methods: Seventy male Sprague-Dawley rats (weighing 220±20 g) were used. All rats fasted 24 hours bef...

Some patients with chronic idiopathic diarrhea have an apparent nonspecific inflammation of colonic mucosa, even though their colons appear normal by barium enema and colonoscopy. This has been referred to as microscopic colitis. However, the significance of this finding is unclear, because the ability of pathologists to accurately distinguish mild degrees of abnormality has not been establishe...

Microscopic colitis (MC) is an inflammatory disease of the colon and a common cause chronic watery diarrhea, predominantly in older patients. encompasses 2 different subtypes, lymphocytic collagenous colitis. The typically appears normal endoscopically MC, diagnosis requires histologic evaluation. Whereas recent studies suggest that incidence MC has plateaued, given aging population, prevalence...

BACKGROUND Therapeutic gene transfer is currently being evaluated as a potential therapy for inflammatory bowel disease. This study investigates the safety and therapeutic benefit of a locally administered lentiviral vector encoding murine interleukin-10 in altering the onset and relapse of dextran sodium sulfate induced murine colitis. METHODS Lentiviral vectors encoding the reporter genes f...

Collagenous colitis and lymphocytic colitis, together constituting microscopic colitis, are common causes of chronic diarrhea. They are characterized clinically by chronic nonbloody diarrhea and a macroscopically normal colonic mucosa where characteristic histopathological findings are seen. Previously considered rare, they now have emerged as common disorders that need to be considered in the ...

Background and objectives: Pelargonium graveolens L'Hér. is an essential oil bearing plant used in traditional medicine of Iran for the treatment of inflammatory disease and pain, anxiety, sadness and also for the relief of gastrointestinal symptoms. Its pharmaceutical product is presently used in Iran for the treatment of depression disorders. Since colitis is a brain...