Any deviation in ambient temperature causes stress and disturbs the cellular homeostasis in the organisms. In the present study, genotoxicity induced by exposure of high temperature (40o, 45o and 50oC) has been analyzed in the third instar larvae of common housefly, Musca domestica, by using chromosome aberration assay, micronucleus assay and mitotic index as cytological end points. The adverse...

BACKGROUND The Brazilian Amazon has suffered impacts from non-sustainable economic development, especially owing to the expansion of agricultural commodities into forest areas. The Tangará da Serra region, located in the southern of the Legal Amazon, is characterized by non-mechanized sugar cane production. In addition, it lies on the dispersion path of the pollution plume generated by biomass ...

Mitotic root micronucleus (MCN) frequency in Vicia faba as a bioassay, is primarily based on the extent of the sentinel Vicia response in terms of cytogenetic damage quantitatively or qualitatively to indicate the presence of mutagenic contaminants. This paper describes an investigation designed to assess changes in MCN frequencies of Vicia faba from three generation plants obtained, respective...

Background: Ionizing radia on irradiated from iodine-131 can induce DNA damage and cell death. The cellular DNA damage is the cause of muta on and cancer. The micronucleus assay in polychroma c erythrocytes was applied to assess the radio-protec ve effect of Turmeric extract on genotoxic poten al of iodine therapy. Materials and Methods: Thirty six male albino rats were randomly divided in six ...

Autoimmune diseases (AD) are classified into organ-specific, systemic, and mixed; all forms of AD share a high risk for cancer development. In AD a destructive immune response induced by autoreactive lymphocytes is started and continues with the production of autoantibodies against different targets; furthermore apoptosis failure and loss of balance in oxidative stress as a consequence of local...

Disinfection of surface drinking water, particularly water chlorination, produces by-products with potential genotoxic and/or carcinogenic activity. A study carried out at a pilot plant for drinking water disinfection of lake water revealed mutagenic activity of three different disinfectants (sodium hypochlorite, chlorine dioxide and peracetic acid) in different seasons using in situ mutagenici...

CONTEXT AND OBJECTIVE Pap smears are the most common and inexpensive screening method for cervical cancer. We analyzed micronucleus prevalence in exfoliated cervical mucosa cells, to investigate associations between increased numbers of micronuclei and risk factors for cervical cancer. DESIGN AND SETTING Analytical cross-sectional study, at Instituto de Pesquisa em Oncologia (IPON). METHODS...

OBJECTIVES The dose-response relationship of radiation-induced bystander effect (RIBE) is controversial at high dose levels. The aim of the present study is to assess RIBE at high dose levels by examination of different endpoints. MATERIALS AND METHODS This experimental study used the medium transfer technique to induce RIBE. The cells were divided into two main groups: QU-DB cells which rece...

Micronucleus (MN) expression in Peripheral blood lymphocytes is well established as a method to monitor chromosome damage in human populations. The use of MN as a measure of chromosome damage in peripheral blood lymphocytes was first proposed by Countryman and Heddle and subsequently improved with the development of the cytokinesis-block micronucleus (CBMN) method, which has been extensively us...

As a well known anti-neoplastic drug, the cytogenotoxicity of methotrexate (MTX) has received more attention in recent years. To develop a new cytoprotector to reduce the risk of second cancers caused by methotrexate, an umu test combined with a micronucleus assay was employed to estimate the cytoprotective effects of ten kinds of bioactive phytochemicals and their combinations. The results sho...