Micronucleus (MN) is a biomarker widely used in biomonitoring studies carried out to determine the genetic risk associated to pesticide exposure. Many in vitro and in vivo studies, as well as epidemiological approaches, have demonstrated the ability of certain chemical pesticides to produce genetic effects including cancer and other chronic pathologies in humans; thus, biomonitoring studies hav...

INTRODUCTION Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis. In rats, methotrexate is known to induce micronuclei formation, leading to genetic damage, while vitamin A is known to protect against such methotrexate-induced genetic damage. Leucovorin...

The dynamic nature of the nuclear envelope (NE) is often underestimated. NE protects, regulates, and organizes eukaryote genome adapts to epigenetic changes its environment. morphology characterized by a wide range diversity abnormality such as invagination blebbing, it diagnostic factor for pathologies cancer. Recently, micronuclei, small nucleus that contains full chromosome or fragment there...

Antineoplastic drugs (ANPDs) are a heterogeneous group of chemicals that include alkylating agents (e.g., cyclophosphamide, melphalan, chlorambucil), antimetabolites (e.g., thioguanine, 5-fluorouracil, methotrexate), antibiotics (e.g., doxorubicin), mitotic spindle inhibitors (e.g., vincristine), hormones (e.g., diethylstilbestrol, free radical generators (e.g., bleomycin) and topoisomerase inh...

Background & Objective: Micronucleus assay of buccal mucosa cells is a simple bio- monitoring method for diagnosing the genetic damages of toxic agents. The aim was to study the genotox...