CONTEXT Pycnogenol(®) extracted from French maritime pine bark (Pinus pinaster Ait. subsp. atlantica) is functional for its antioxidant activity. OBJECTIVE To investigate the effects of Pycnogenol(®) on bone mineral density (BMD), trabecular microarchitecture and bone metabolism in ovariectomized (OVX) rats. MATERIALS AND METHODS Thirty Sprague-Dawley rats were randomized into 3 groups: SHA...

Information regarding the alteration of trabecular bone microarchitecture, which is one of the important criteria to estimate bone condition, induced by osteoarthritis (OA) is sparse. The current study therefore aimed to identify and quantify patterns of alterations in trabecular bone microarchitectural characteristics at tibial epiphysis induced by OA using in vivo microcomputed tomography. Fo...

Growth hormone (GH) deficiency is related to an increased fracture risk although it is not clear if this is due to compromised bone quality or a small bone size. We investigated the relationship between bone macrostructure, microarchitecture and mechanical properties in a GH-deficient (GHD) mouse model undergoing GH treatment commencing at an early (prepubertal) or late (postpubertal) time poin...

Recent studies suggested that Eurycoma longifolia, a herbal plant, may have the potential to treat osteoporosis in elderly male. This study aimed to determine the effects of Eurycoma longifolia supplementation on the trabecular bone microarchitecture of orchidectomised rats (androgen-deficient osteoporosis model). Forty-eight-aged (10-12 months old) Sprague Dawley rats were divided into six gro...

In vivo assessment of trabecular bone microarchitecture could improve the prediction of fracture risk and the efficacy of osteoporosis treatment and prevention. Geodesic topological analysis (GTA) is introduced as a novel technique to quantify the trabecular bone microarchitecture from high-spatial resolution magnetic resonance (MR) images. Trabecular bone parameters that quantify the scale, to...

Platform desertion, or a developer’s stopping the development of an app for a platform, is a widespread phenomenon to the detriment of platforms. However, the extant literature focuses primarily on why app developers join—not leave—a platform. This app-level study develops two ideas: (a) coordination costs borne by an app’s developer are associated with platform desertion, and (b) these costs a...

Total joint replacement surgery is being performed on an increasingly large part of the population. Clinical longevity of implants depends on their osseointegration, which is influenced by the load, the characteristics of the implant and the bone-implant interface, as well as by the quality and quantity of the surrounding bone. Aseptic loosening due to periprosthetic osteolysis is the most freq...

Microprocessor performance can be improved by increasing either the clock frequency (GHz) or the instruction level parallelism (IPC) or both. There is a complex and adversarial relationship between increasing GHz and increasing IPC. This talk revisits the old “speed-demons vs. brainiacs” debate (in some sense the reincarnation of the “RISC vs. CISC” debate) and recasts it as the tension between...

Strontium (Sr) ralenate is a new agent used for the prevention and treatment of osteoporosis. As a boneseeking element, 98% of Sr is deposited in the bone and teeth after oral ingestion. However, the effect of Sr treatment on bone microarchitecture and bone nanomechanical properties remains unclear. In this study, 18 osteoporotic goats were divided into four groups according to the treatment re...

The PowerTimer toolset has been developed for use in earlystage, microarchitecture-level power–performance analysis of microprocessors. The key component of the toolset is a parameterized set of energy functions that can be used in conjunction with any given cycle-accurate microarchitectural simulator. The energy functions model the power consumption of primitive and hierarchically composed bui...