A unique sequence within the giant titin molecule, the PEVK domain, has been suggested to greatly contribute to passive force development of relaxed skeletal muscle during stretch. To explore the nature of PEVK elasticity, we used titin-specific antibodies to stain both ends of the PEVK region in rat psoas myofibrils and determined the region's force-extension relation by combining immunofluore...

3D electron diffraction (3D ED), also known as micro-crystal (MicroED), is a rapid, accurate, and robust method for structure determination of submicron-sized crystals. ED has mainly been applied in material science until 2013, when MicroED was developed studying macromolecular considered cryo-electron microscopy method, data collection usually carried out cryogenic conditions. As result, some ...

Doxorubicin has become one of the most effective chemotherapeutic agents, but its use was complicated by development heart failure. Proposed mechanisms for antitumor effects included intercalation into DNA that caused prevention micro molecule synthesis, cross-linkage and binding, damage due to topoisomerase 2b suppression, reactive oxygen species production, induction apoptosis. Several drugs ...

Local thermal management has important implications regarding comfort, energy consumption, and electronic device performance/lifetime. While organic thermoelectrics have emerged as promising materials for flexible thermoelectric harvesting devices, their potential Peltier cooling element been largely overlooked. Here, micro-thermoelectric coolers based on doped small molecule thin-films with a ...

PURPOSE Leukemia inhibitory factor (LIF) is a pleiotropic molecule of the interleukin 6 family of cytokines. We aimed to examine the safety, pharmacokinetics, and biological effects of recombinant human LIF (rhLIF, emfilermin) in patients with advanced cancer. EXPERIMENTAL DESIGN In stage 1 of the study, 34 patients received rhLIF or placebo (3:1 ratio) at doses of 0.25-16.0 micro g/kg/day or...