PURPOSE The aim was to evaluate outcomes and predictors for anatomical success in macular hole (MH) surgery. MATERIALS AND METHODS This was a prospective cohort study of patients operated for idiopathic MH with stages II, III or IV. Patients underwent pars plana vitrectomy with internal limiting membrane (ILM) peeling, internal gas tamponade, and postoperative face down positioning. The prima...

INTRODUCTION As manuka honey (MH) exhibits immunoregulatory and anti-staphylococcal activities, we aimed to investigate if it could be effective in the treatment of atopic dermatitis (AD). METHODS Adult volunteers with bilateral AD lesions were asked to apply MH on one site overnight for seven consecutive days and leave the contralateral site untreated as possible. Three Item Severity score w...

Low birth weight is associated with reduced bone mass and density in adult life. However, effects of maternal hypoxia (MH) on offspring bone development are not known. Objective. The current study investigated the effects of fetal growth restriction induced by MH during the last half of gestation on bone structure and volume in the offspring of the fetus near term and the pup in adolescence. Me...

BACKGROUND Malignant hyperthermia (MH) is associated, in the majority of cases, with mutations in RYR1, the gene encoding the skeletal muscle ryanodine receptor. Our primary aim was to assess whether different RYR1 variants are associated with quantitative differences in MH phenotype. METHODS The degree of in vitro pharmacological muscle contracture response and the baseline serum creatine ki...

The possibility of chemical modification of peptides and proteins under the condition of proteolytic digestions and FABMS analysis was investigated. The results ;indicate that among the amino acid constituents of peptides and proteins: serinefcysteine, and cystine are the most sensitive residues which undergo chemical modificadons under the exprimenta1 conditions. The chemical modification ...

Ao redor do mundo, o câncer vem se consolidando como uma das principais causas de morte na sociedade contemporânea. A Agência Internacional Pesquisa sobre Câncer – IARC, órgão vinculado à Organização Mundial da Saúde ­– OMS, estima que em 2020 houve 19,3 milhões novos casos e 9,96 mortes decorrentes neoplasias malignas. Apesar dos afetarem pacientes diferentes nacionalidades, culturas etnias, a...

We have investigated if cultivated muscle cells from malignant hyperthermia (MH) patients can be distinguished pharmacologically from controls. Muscle specimens from four individuals carrying the Gly2435Arg mutation of the skeletal muscle ryanodine receptor protein (RYR1) and from four controls were used to culture myotubes. Resting intracellular calcium concentration ([Ca2+]i) of MH myotubes w...

BACKGROUND Inadequate access to mental health (MH) services in Lebanon, where prevalence is noteworthy, is a concern. Although a multitude of factors affects access to services, lack of financial coverage of MH services is one that merits further investigation. AIM OF THE STUDY This study aims at providing a systematic description of MH financing systems with a special focus on Lebanon, prese...

S ome untreated subjects show normal clinic but high home or ambulatory blood pressure (BP). This phenomenon has been called masked hypertension (MH) and may be determined by various factors. The same experience may be observed in treated hypertensive patients and has been labeled with the same term. The prevalence of MH in treated hypertension is variable, from 7% to 20%, depending on differen...

Novel inorganic alkali and alkaline earth hydrides of the f o r m u l a MH *, MH 2 * , and MH X * wherein M is the metal, X , is a halide, and H * comprises a novel high binding energy hydride ion were synthesized in a high temperature gas cell by reaction of atomic hydrogen with a catalyst and MH , MH 2 , or MX corresponding to an alkali metal or alkaline e a r t h metal compound, respectively...