One hundred and fifty patients with migraine attacks attending the Copenhagen acute migraine clinic were treated either with metoclopramide 10 mg i.m. metoclopramide 20 mg as suppository or placebo in a double blind trial. All patients simultaneously or 30 minutes later received paracetamol 1 g and diazepam 5 mg orally. The nausea was relieved in 71% of the patients by placebo and bed rest, but...

BACKGROUND Metoclopramide is a centrally acting antiemetic and ketamine is a general anesthetic used with sedatives, tranquilizers and analgesics. Metoclopramide has analgesic effects and its combination with ketamine causes sedation and hypnosis. The contribution of metoclopramide to the analgesic effect of ketamine is not known. The purpose of the present study was to explore the analgesic ef...

To the Editor: In the otherwise excellent review article "Anaesthesia and emesis, II" by Palazzo and Strunin, ~ the section devoted to metoclopramide is perhaps open to comment. Reference is made to Davies and Howells' paper on the ability of metoclopramide to empty the stomach following injury, 2 which did not differentiate between liquid and solid gastric content. Hancock 3 showed no differen...

OBJECTIVE To evaluate the effects of metoclopramide-induced hyperprolactinemia on the prolactin receptor of murine endometrium. DESIGN Experimental study using the RNA extraction to detect tissue prolactin receptor isoforms by reverse-transcriptase polymerase chain reaction (RT-PCR). SETTING University-based laboratory. ANIMAL(S) Seventy-two female swiss albino mice (Mus musculus), approx...

to be palatopharyngeal myoclonus/tremor and posited a direct relationship to metoclopramide. The drug was stopped and her symptoms subsided over approximately 8 hours. Palatopharyngeal myoclonus is typically a slow form of tremor at 1 to 4 Hz. It can involve the pharynx, larynx, diaphragm, and extend to involve even eye muscles. The rhythmic movement can occur both during phonation and at rest....

Objective To compare the efficacy of combined electroacupuncture and metoclopramide treatment with that of metoclopramide only in improving gastric emptying in critically ill neurosurgical patients. Methods In this prospective case-control pilot study, a total of 16 adult critically ill mechanically ventilated patients who were treated in the surgical intensive care unit were enrolled. Electr...

The efficacy of metoclopramide for preventing organophosphate insecticide-induced (diazinon) toxicosis was evaluated in 7~14 days old chicks. Injection of metoclopramide at 25 mg/kg, s.c. 15 min before diazinon increased the oral 24 h median lethal dose of the insecticide in the chicks by 80%. Metoclopramide alone inhibited the in vitro and in vivo plasma and whole brain cholinesterase activiti...

Metoclopramide has been used for almost 40 yr to prevent postoperative nausea and vomiting (PONV). We have reviewed the efficacy and safety of metoclopramide for the prevention of PONV. A systematic search (MEDLINE, EMBASE, manufacturers' databases, hand searching, bibliographies, all languages, up to June 1998) was performed for full reports of randomized comparisons of metoclopramide with pla...

In a randomized, double-blind study, we have compared the prophylactic antiemetic efficacy of ondansetron with that of metoclopramide in 123 patients undergoing general anaesthesia for day-case gynaecological laparoscopic surgery. The patients received either i.v. ondansetron 4 mg or metoclopramide 10 mg immediately before a standard anaesthetic. The number of patients with no nausea or vomitin...

a mixture of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride is used for the symptomatic treatment of common cold. in this study, a derivative spectrophotometric method based on zero-crossing technique was proposed for simultaneous determination of acetaminophen, diphenhydramine hydrochloride and pseudoephedrine hydrochloride. determination of these drugs was perf...