The effect of chronic angiotensin I converting enzyme inhibition on the pressure-natriuresis relation was studied in Wistar-Kyoto and spontaneously hypertensive rats. Enalapril maleate (25 mgkg"'day"' in drinking water) was started at 4-5 weeks of age. At 7-9 weeks of age, the pressure-natriuresis relation was studied while the rats were under Inactin anesthesia 1 week after the right kidney an...

An 18-months-old Thoroughbred filly weighing 400 kg presented at the Rural Veterinary Centre 12 h after running through a fence. Two hours before presentation the filly showed signs of depression and reluctance to move. Physical examination revealed an increased heart rate (80 beats/min) and respiratory rate (40 breaths /min) and reduced gastrointestinal motility on auscultation of the abdomen....

The synthetic vasopressin (AVP) analogue desmopressin (dDAVP) has been used as pharmacological function test to quantify vasopressinergic co-activation of the hypothalamus-pituitary-adrenal (HPA) axis in the past. Such exogenous vasopressinergic stimulation may induce confounding cardiovascular, pro-coagulatory and anti-diuretic effects and low endogenous corticotrophin-releasing-hormone (CRH) ...

AIM To determine if reported lower plasma concentrations of artemisinin derivatives for malaria in pregnancy result from reduced oral bioavailability, expanded volume of distribution or increased clearance. METHODS In a sequentially assigned crossover treatment study, pregnant women with uncomplicated falciparum malaria received i.v. artesunate (i.v. ARS) (4mgkg(-1) ) on the first day and ora...

Heavy metals are notoriously toxic pollutants which can potentially harm living beings and serious health hazards. The aim of the present study was to assess levels cadmium (Cd) nickel (Ni) throughout year in urban areas densely populated industrial city Faisalabad eight commonly raised ornamental tree species with phytoremediation potential. High Cd Ni were recorded all areas, spatio-temporal ...

UNLABELLED Domperidone (dopamine antagonist), metoclopramide and clebopride (both dopamine antagonists and stimulators of the intramural cholinergic system), and trimebutine (spasmolytic) are used in the treatment of digestive disorders such as dyspepsia or gastritis. Our aim was to compare the effects of these compounds on the isolated intact gastroduodenal preparation of the guinea pig. Dompe...

BACKGROUND The synthesis of albumin after oral ingestion of nutrients provides a means of storing amino acids, which can be made available during periods of fasting. OBJECTIVE This study was undertaken to see whether the response of albumin synthesis to the oral intake of nutrients is compromised in elderly subjects. DESIGN Albumin synthesis was determined from the incorporation of 43 mg l-...

Metoclopramide was described in 1964 as an anti-emetic drug and stimulant of gastrointestinal motility. Dopamine D2 receptor antagonism explained the anti-emetic activity and was suggested to stimulate gastrointestinal motility. An important use of metoclopramide and other D2 receptor antagonists is to inhibit emesis caused by anticancer chemo radiotherapy. However, the use of new platinum-base...