نتایج جستجو برای: methyltransferase

تعداد نتایج: 22647  

Journal: :Journal of Investigative Dermatology 2022

UV-induced DNA damage is repaired by nucleotide excision repair (NER) that corrects bulky helix-distorting lesions across the whole genome and essential for preventing mutagenesis skin cancer. Here we show METTL14 (methyltransferase-like 14), a critical component of m6A RNA methyltransferase complex, promotes through regulating mRNA methylation-mediated translation NER factor DDB2 suppresses tu...

Hekmatimoghaddam , Seyedhossein , Pourrajab , Fatemeh , Rostamian , Tohid ,

Background: 6-thioguanine (6-TG) is one of the thiopurine drugs with successful use in oncology, especially for acute lymphoblastic leukemia (ALL). 6-TG is proposed to act as an epigenetic drug affecting DNA methylation. The aim of this study was to clarify the effect of 6-TG on the proliferation, viability and expression of genes coding for the enzymes DNA methyltransferase 3A and DNA methyltr...

Journal: :Genetics 2014
Meera Govindaraghavan Sarah Lea Anglin Aysha H Osmani Stephen A Osmani

Mitosis is promoted and regulated by reversible protein phosphorylation catalyzed by the essential NIMA and CDK1 kinases in the model filamentous fungus Aspergillus nidulans. Protein methylation mediated by the Set1/COMPASS methyltransferase complex has also been shown to regulate mitosis in budding yeast with the Aurora mitotic kinase. We uncover a genetic interaction between An-swd1, which en...

Journal: :Alimentary pharmacology & therapeutics 2004
J Winter A Walker D Shapiro D Gaffney R J Spooner P R Mills

BACKGROUND Azathioprine is a useful agent in the management of inflammatory bowel disease. Its use is limited by its side-effect profile. Marrow toxicity occurs in approximately 3.2% of patients and is known to be associated with diminished thiopurine methyltransferase enzyme activity resulting from genetic polymorphisms. AIM To evaluate the cost-effectiveness of screening for thiopurine meth...

Journal: :The Journal of biological chemistry 2016
Joshua P Owings Emily G Kuiper Samantha M Prezioso Jeffrey Meisner John J Varga Natalia Zelinskaya Eric B Dammer Duc M Duong Nicholas T Seyfried Sebastián Albertí Graeme L Conn Joanna B Goldberg

Pseudomonas aeruginosa is a Gram-negative opportunistic pathogen that trimethylates elongation factor-thermo-unstable (EF-Tu) on lysine 5. Lysine 5 methylation occurs in a temperature-dependent manner and is generally only seen when P. aeruginosa is grown at temperatures close to ambient (25 °C) but not at higher temperatures (37 °C). We have previously identified the gene, eftM (for EF-Tu-modi...

Journal: :The Plant cell 2003
Chloe Zubieta Jeannine R Ross Paul Koscheski Yue Yang Eran Pichersky Joseph P Noel

Recently, a novel family of methyltransferases was identified in plants. Some members of this newly discovered and recently characterized methyltransferase family catalyze the formation of small-molecule methyl esters using S-adenosyl-L-Met (SAM) as a methyl donor and carboxylic acid-bearing substrates as methyl acceptors. These enzymes include SAMT (SAM:salicylic acid carboxyl methyltransferas...

Journal: :Archives of biochemistry and biophysics 1997
R M Kagan A Niewmierzycka S Clarke

The methylation of abnormal L-isoaspartyl residues by protein L-isoaspartate (D-aspartate) O-methyltransferase (EC 2.1.1.77) can lead to their conversion to L-aspartyl residues. For polypeptides damaged by spontaneous reactions that generate L-isoaspartyl residues, these steps represent a protein repair pathway that can limit the accumulation of potentially detrimental proteins in the aging pro...

Journal: :Applied and environmental microbiology 1989
K Yabe Y Ando J Hashimoto T Hamasaki

The substances belonging to the sterigmatocystin group bear a close structural relationship to aflatoxins. When demethylsterigmatocystin (DMST) was fed to Aspergillus parasiticus NIAH-26, which endogenously produces neither aflatoxins nor precursors in YES medium, aflatoxins B1 and G1 were produced. When dihydrodemethylsterigmatocystin (DHDMST) was fed to this mutant, aflatoxins B2 and G2 were ...

Journal: :Clinical science 1988
G D Henderson R E Ruffin J H Alpers A J Crockett D A Schembri K M Latimer

1. N-Methyltransferase activity was measured in surgical specimens of human lung using phenylethanolamine as substrate. Thirty-three male and seven female patients, age range 19-78 (median 62.5) years were studied. The activity in lung homogenates was 0.59 x 10(-6) units/mg of protein (SEM 0.03, n = 40), with a range of 0.16-1.16 x 10(-6) units/mg of protein. There was no difference (P = 0.97) ...

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