Introduction: Definite Meniere's diseaseis associated with two or more definitive periods of vertigo along with hearing loss, plus tinnitus or aural fullness or both. This study aimed to compare the effect of intratympanic dexamethasone and methylprednisolone on the functional-level scale of pure-tone audiometry (PTA), and class outcome measures of vertigo.  Materials and Methods: In this clini...

The repair of peripheral nerve injuries is still one of the most challenging tasks and concerns in neurosurgery. Effect of methylprednisolone-laden hydrogel loaded into a chitosan conduit on the functional recovery of peripheral nerve using a rat sciatic nerve regeneration model was assessed. A 10-mm sciatic nerve defect was bridged using a chitosan conduit (CHIT/CGP-Hydrogel) filled with CGP-h...

BACKGROUND Overuse tendon injuries are frequent. Corticosteroid injections are commonly used as treatment, although their direct effects on the material properties of the tendon are poorly understood. PURPOSE To examine the influence of corticosteroids on the tensile strength of isolated collagen fascicles. STUDY DESIGN Controlled laboratory study. METHODS Single strands (300-500 mum) of ...

OBJECTIVE To compare the effect of two different corticosteroid types in bilateral and symmetrical knee osteoarthritis (OA). METHODS One hundred and twenty-six patients received injections of methylprednisolone acetate (MP) in one knee and triamcinolone hexacetonide (TH) in the contralateral knee. Patients were evaluated before injection and 2, 4, 8, 12, and 24 weeks after. RESULTS Mean pat...

We report herein a patient with subglottic granuloma after removal of a minitracheostomy tube (Minitrach II, SIMS Portex Inc., Hythe, Kent, UK). The patient underwent pulmonary resection for lung cancer followed by insertion of the minitracheostomy tube for prevention of sputum retention. The tube was removed 4 days after insertion. Twelve weeks later, the patient developed severe dyspnea and s...

Defining appropriate medical treatment incorporates evidence to balance risk and benefit. Yet, sometimes physicians find themselves in an uncomfortable “gray zone” that necessitates decision making with a paucity of data. This gray zone is where we find ourselves as we struggle to manage an outbreak of central nervous system (CNS) and joint infections that occurred due to injection of methylpre...

background:   objective: it was investigated whether methylprednisolone had a favorable effect on osteoporotic bone tissue in oophorectomy induced osteoporotic rats whose endogenous adrenaline levels are suppressed with metyrosine.   materials and methods: bone mineral density, number of osteoblast-osteoclast, bone osteocalcin levels and alkaline phosphatase (alp) measurements were performed. o...

Although the main hematologic findings, such as spherocytosis, polychromasia, anisopoikilocytosis, and reticulocytosis, etc. and Coombs test results were not given, the patient most likely had hemolytic anemia, for which he was given pulse methylprednisolone (MP) three days after intravenous immunoglobulin (IVIG) therapy, which might also cause encephalopathy. However, the hematologic changes w...