I read with great interest the report by Bessac et al. entitled: “Transient receptor potential ankyrin 1 antagonists block the noxious effects of toxic industrial isocyanates and tear gases (1).” In the introduction the authors mention a variety of environmental exposure scenarios, including Bhopal, India, and a large-scale pesticide spill that occurred on the Sacramento River in Northern Calif...

This paper describes the inadequacies in the response of the Union Carbide Corporation to the accidental release of the highly toxic gas, methyl isocyanate, from its plant in Bhopal, India in 1984. Over 20,000 people are estimated to have died from exposure to this gas since 1984, with some 120,000 chronically ill survivors. Union Carbide fought to avoid compensation or to keep it very low. The...

The world's worst industrial disaster, at Union Carbide, Bhopal, India, took place on 2-3 December 1984, leading to the leakage of poisonous methyl-isocyanate into the environment, causing thousands of deaths, pregnancy loss and for some, incapacitation for life. More than a quarter of a century later, the Indian Council of Medical Research undertook to redefine the abysmal consequences of the ...

The development of isocyanate asthma is little understood. To gain more knowledge in this area, a group of 20 workers occupationally exposed to isocyanates, five subjects with clinical isocyanate asthma, and a control group of 10 people not exposed to isocyanate were examined with lung function tests and a methacholine provocation test. Forced expiratory volume in one second and tests aimed at ...

In this study, we aimed to develop new biologically active compounds with antibacterial properties. 4-amino-5-methyl-2H-1,2,4-triazol-3(4H)-one (1) was converted the corresponding Schiff bases (2) reaction a 4-anis aldehyde. Acetic acid ethyl esters containing [1,2,4] triazole ring (3) were synthesized by condensation of bromoacetate in basic media. The hydrazine hydrate led formation hydrazide...

G31.41+0.31 is a well known chemically rich hot molecular core (HMC). Using Band 3 observations from the Atacama Large Millimeter Array (ALMA), we have analyzed chemical and physical properties of source. We identified methyl isocyanate (CH3NCO), precursor prebiotic molecules, toward In addition to this, reported presence complex organic molecules (COMs) like methanol (CH3OH), methanethiol (CH3...

A chiral selector of cellulose-2,3-bis(3,5-dimethylphenylcarbamate) (CBDMPC) was synthesized by reacting 3,5-dimethylphenyl isocyanate with microcrystalline cellulose dissolved in an ionic liquid of 1-allyl-3-methyl-imidazolium chloride (AMIMCl). The obtained chiral selector was effectively characterized by infrared spectroscopy, elemental analysis and 1H NMR. The selector was reacted with 3-am...

The basic chemical structure of most prostate specific membrane antigen (PSMA) inhibitors which are now in pre-clinical and clinical studies is Glu-Ureido-based peptides. Synthesis of urea-based PSMA inhibitors includes two steps: 1- isocyanate intermediate formation and 2- urea bond formation. In current methods, isocyanate is formed in liquid phase and then reacts with amine existing in liqui...