In vitro inhibition of Ca2+-ATPase by DDT homologs was studied using maternal brush-border membranes from human term placentas as an enzyme source. At 10 microM concentration many of the compounds tested inhibited this enzyme. The order of effectiveness of inhibition was as follows: p,p'-DDE greater than p,p'-DDD greater than p,p'-DDT greater than methoxychlor(mec). Both p,p'-DDOH and p,p'-DDA ...

Rate of Circulation of the Body Fluid in Adult Tenebrio molitor Linnaeus, Anasa tristis (de Geer), and Murgantia histrionica (Hahn): Roderick Craig and N. A. Olson 648 An Instance of the Occurrence of Carcinogenic Substances in Certain Barnacles: Michael B. Shimkin, B. Kenneth Koe, and L. Zechmeister _ 650 An Analog of Histamne that Stimulates Gastric Acid Secretion without other Actions of His...

Methoxychlor (MXC), an organochlorine pesticide, and its metabolites, mono-hydroxy MXC (MOH) and bis-hydroxy MXC (HPTE) are known ovarian toxicants and can cause inhibition of antral follicle growth. Since these chemicals bind to estrogen receptor alpha (ESR1), we hypothesized that ovaries overexpressing ESR1 (ESR1 OE) would be more susceptible to toxicity induced by MXC and its metabolites bec...

Transgenerational effects of environmental toxins require either a chromosomal or epigenetic alteration in the germ line. Transient exposure of a gestating female rat during the period of gonadal sex determination to the endocrine disruptors vinclozolin (an antiandrogenic compound) or methoxychlor (an estrogenic compound) induced an adult phenotype in the F1 generation of decreased spermatogeni...

A study was undertaken to determine the extent of organochlorine pesticide (OP) and polychlorinated biphenyl (PCB) contamination in infant formula milk and in the human milk, fat and serum of women from an agricultural area in Southern Spain. A procedure is proposed that simultaneously detects trace levels of lindane, endosulfan-ether, vinclozolin, aldrin, endosulfan-lactone, endosulfan-alpha, ...

In the face of evidence of human milk contamination by organochlorine pesticides, an analysis was performed on samples of milk obtained from healthy lactating women in the provinces of Granada and Almeria in Southern Spain. The samples were obtained by the Neonate Section of the Department of Pediatrics of Granada University Hospital (Neonatology Division) and by the Neonatal Service of Ponient...