Background: Needle sharing and sexual contacts Taiwanese Department of Health (DOH) among injecting drug users (IDUs) have become laden with HIV and HIV related health problems, representing a serious public health threat all over the world. For reduce the sharing of needle, Taiwanese public health prompted methadone maintenance treatment (MMT) to reduce needle sharing and curb the transmission...

BACKGROUND To estimate the incidence of Hepatitis C virus (HCV) and the predictive factors through repeated routine laboratory analyses. METHODS An observational cohort study was carried out in Quatre Camins Prison, Barcelona. The study included subjects with an initial negative HCV result and routine laboratory analyses containing HCV serology from 1992 to 2011. The incidence of infection wa...

Cytochrome P450; Drug Interactions; CYP3A4; CYP2D6; Metabolites; Opioids. Introduction metabolism of codeine, fentanyl, methadone, oxycodone, and . WebMD provides information about interactions between Codeine Sulfate Oral and. Buprenorphine effects in methadone-maintained volunteers: effects at two . Methadone is a potent drug, and can interact with other drugs to have block the high of other ...

BACKGROUND This study aimed to investigate the prevalence of diversion and injection of methadone and buprenorphine among clients receiving opioid pharmacotherapy treatment at community pharmacies in New South Wales (NSW), Australia. METHODS A multi-site cross-sectional survey design was utilised using a self-complete questionnaire. Participants were 508 clients receiving supervised methadone...

AIMS To assess the acute-on-chronic effects of methadone on drug craving, mood and cognitive and psychomotor functioning in patients on long-term methadone substitution treatment. DESIGN AND PARTICIPANTS A double-blind, cross-over design was used to compare the effects of a 33% increase in patient's daily dosage of methadone with a matched placebo linctus. Eighteen patients completed the stud...

U P UNTIL NOW, CINEMATIC PRISON METAPHORS HAVE BEEN NEGLECTED by both metaphor and film studies. By focusing on these ignored types of metaphor, this article fills a crucial gap in the critical understanding of metaphor. The first part of this article develops a taxonomy of prison and film metaphors. The first taxonomy (of prison metaphors) is based on the categories developed by Monika Fludern...

AIM The injection of non-sterile methadone designed for oral consumption is associated with serious health risks. There is only a small number of studies on this topic, with divergent results. The main aim of the present study was to obtain data on the frequency of methadone injecting in a state out-patient clinic specialised in substance use disorders. METHODS Eighty patients in methadone ma...

We present a case of T.M. admitted to University Department of Psychiatry, Split University Hospital Center, in Croatia, because of the acute psychotic reaction (F23.9). The patient's urine tested positive for methadone without a history of methadone ingestion. Urine drug screen was performed with the COBAS Integra Methadone II test kit (kinetic interaction of microparticles in solution /KIMS/ ...

Gas chromatography-mass spectrometry quantitative method was developed to monitor concentrations of methadone and its metabolite 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) in plasma and urine of patients. The developed method was simple, accurate and reproducible to quantify methadone and EDDP in plasma and urine samples in the concentration range of 15-1,000 and 50-2,000 ng/mL, r...

OBJECTIVE To examine the population-wide overdose risk emerging from the prescription of methadone and buprenorphine for opioid substitution treatment in England and Wales. DESIGN Retrospective administrative data study. SETTING National databases for England and Wales. PARTICIPANTS/CASES Drug-related mortality data were drawn from the Office for National Statistics, and prescription data...