BACKGROUND Lung cancers account for the majority of brain metastases which pose major therapeutic challenges. Biomarkers prognosticating for the development of brain metastases in patients with non-small cell lung cancers (NSCLC) may improve personalized care. Six serum proteomic biomarkers were previously investigated at Memorial Sloan Kettering but their associations with brain metastases wer...

BACKGROUND Approximately one quarter of patients with colorectal carcinoma (CRC) have distant metastases at initial dia-gnosis and almost 50% will develop them during the disease course. Only radical surgical resection of metastases improves clinical outcome and offers a chance of longterm survival. Initially unresectable metastases can become resectable after downsizing with systemic therapy. ...

OBJECTIVE To see whether parathyroid hormone related protein has a humoral role in breast cancer. DESIGN Plasma concentrations and tumour expression of parathyroid hormone related protein were determined (by two site immunoradiometric assay and immunohistochemistry respectively) in women with breast cancer and related to the presence of bone metastases and serum calcium concentrations. SUBJ...

Aim To establish a new Japanese classification of synchronous peritoneal metastases from colorectal cancer. Methods This multi-institutional, prospective, observational study enrolled patients who underwent surgery for cancer with metastases. Overall survival rates were compared according to the various models using objective indicators. Each model was evaluated by Akaike's information criterio...

Abstract Brain metastases are frequently seen in neurosurgical practice. Standardised criteria created to better classify these common pathologies research studies. This study’s goal was evaluate RANO-BM (Response Assessment Neuro-Oncology - Metastases) criteria’s current thresholds a cohort of patients with brain managed by stereotactic radiosurgery (SRS). We performed retrospective metastasis...

Aim Patients with locally recurrent rectal cancer (LRRC) frequently present either synchronous metastases or a history of metastases. This study was conducted to evaluate whether LRRC patients without have different oncological outcome compared treated curative intent potentially curable Method All consecutive who underwent intentionally surgery between 2005 and 2017 in large tertiary hospital ...

BACKGROUND: Metastases are simply known as cancers spread to another part of the body, and often be responsible for severity cancer prognosis. Somehow, complex mechanisms metastases not fully understood yet.CONTENT: The characteristic is akin a never-healing wound. Cancer cells plastic dynamic they build their niches developed into metastases, even when seem dormant. Therefore, can survive immu...

introduction: involvement of the skeleton can cause an excruciating pain in two-thirds of terminal patients with a history of malignancy. due to several limitations of other therapies, such as analgesics, bisphosphonates, chemotherapy, hormonal therapy and external beam radiotherapy; bone-seeking radiopharmaceuticals have an important role in palliation of pain from bone metastases. although th...