BACKGROUND Obesity is associated with severe co-morbidities such as type 2 diabetes and nonalcoholic steatohepatitis. However, studies have shown that 10-25 percent of the severely obese individuals are metabolically healthy. To date, the identification of genetic factors underlying the metabolically healthy obese (MHO) state is limited. Systems genetics approaches have led to the identificatio...

Obesity is a recognized global epidemic. Obese individuals are at increased risk for type 2 diabetes mellitus (T2DM), and both obesity and diabetes are known risk factors for dementia, another global public health issue. This paper reviews research on the link between obesity, (T2DM), and dementia, with an emphasis on visceral obesity. Some obese individuals, the metabolically healthy obese, do...

INTRODUCTION The purpose of this study was to examine levels of physical activity (PA) and screen time (ST) in metabolically healthy obese (MHO) and metabolically unhealthy obese (MUO) adolescents and adults. METHODS NHANES data from obese adolescents (12-18 years, BMI z-score ≥ 95th percentile) and adults (19-85 years, BMI ≥ 30 kg/m(2)) were pooled from 2003-2005 cycles. Metabolic phenotypes...

OBJECTIVE This study examines the association between incident mobility limitation and 4 lifestyle factors: smoking, alcohol intake, physical activity, and diet in well-functioning obese (n = 667) and non-obese (n = 2027) older adults. RESEARCH METHODS AND PROCEDURES Data were from men and women, 70 to 79 years of age from Pittsburgh, PA and Memphis, TN, participating in the Health, Aging and...

OBJECTIVE Obesity often clusters with other major cardiovascular disease risk factors, yet a subset of the obese appears to be protected from these risks. Two obesity phenotypes are described, (i) "metabolically healthy" obese, broadly defined as body mass index (BMI) ≥ 30 kg/m(2) and favorable levels of blood pressure, lipids, and glucose; and (ii) "at risk" obese, BMI ≥ 30 with unfavorable le...

Abstract Background Whether the metabolically healthy obese (MHO) phenotype is a single, stable or transitional, fluctuating state currently unknown. The Mexican-Mestizo population has genetic predisposition for development of type 2 diabetes (T2D) and other cardiometabolic complications. Little known about natural history metabolic health in this population. aim study was to analyze transition...

Abstract Background Whilst current evidence are in favour of metabolic health and non-obesity the reduction incident cardiovascular disease, little is known regarding prognosis across phenotypes once disease occurs. This study examined patients with significant aortic stenosis (AS) based on presence obesity. Methods retrospective cohort consecutive presenting moderate-to-severe AS to a tertiary...

posity is used, the metabolically healthy but obese phenotype is a benign condition, with a better prognosis (30–50% lower risk) for mortality and morbidity than metabolically abnormal obese people. Interestingly, no difference in the prognosis is observed between metabolically healthy but obese individuals and metabolically healthy normal-fat individuals once fitness is accounted for, suggesti...