vascular arrangement is in fact a feature of all human lymph nodes. Our study was designed to reinvestigate this traditional view of lymph nodal vascular supply. The arterial tree supplying lymph nodes from human cadavers was injected with a radio-opaque barium suspension (75%w/v). Superficial lymph nodes from the groin and deep lymph nodes from the small intestinal mesentery were studied by me...

Bestatin, a low-molecular weight dipeptide, is a potent inhibitor of aminopeptidase N which has been demonstrated to have antitumor and immunomodulatory effects. The effects of bestatin (10, 1 and 0.1 mg/kg) administered intraperitoneally once, five or ten times to mice on the total number of lymphocytes in the thymus, spleen and mesenteric lymph nodes and the percentage and the absolute number...

The comprehension of the immune responses in infectious diseases is crucial for developing novel therapeutic strategies. Here, we review current findings on the dynamics of lymphocyte subpopulations following experimental acute infection by Trypanosoma cruzi, the causative agent of Chagas disease. In the thymus, although the negative selection process of the T-cell repertoire remains operationa...

The effects of dietary lipids on the abundance of dendritic cells in adipose tissue in anatomically defined relationships to chronically inflamed lymph nodes were investigated in mature male rats fed plain chow or chow plus 20 % sunflower-seed or fish oil. The popliteal lymph nodes were stimulated by local subcutaneous injection of 20 microg lipopolysaccharide to both hindlegs three times/week ...

Presentation of peptide:MHCII by RORγ-expressing group 3 innate lymphoid cells (ILC3s), which are enriched within gut tissue, is required for control of CD4 T-cell responses to commensal bacteria. It is not known whether ILC populations migrate from their mucosal and peripheral sites to local draining secondary lymphoid tissues. Here we demonstrate that ILC3s reside within the interfollicular a...

Lanthanum carbonate (LaCO(3)) is an oral phosphate binder widely used in end-stage renal disease (ESRD). Preclinical animal studies reported the highest La concentrations outside the gut to be in mesenteric lymph nodes. We observed previously unreported La deposition visible by light microscopy and confirmed by scanning electron microscopy with energy dispersive x-ray spectroscopy in a mesenter...

background: the impact of positive intramammary lymph node (im ln) on the prognosis of patients with breast cancer has been debated for years; likewise, the standard management of patients with positive im ln remains unclear, especially when it is identified by preoperative imaging or by sentinel lymph node biopsy. the present study aims at reviewing the level of concurrent involvement of im ln...

510 cases of surgical lymph node biopsies during a five year periode are reviewed with the following conclusionsthe lymph node biopsy constitues 5% of all the surgical biopsies, the cervical and axillary lymph nodes are the most commonly biopsicd nodes due to their easy accessibility and due to the fact that they drain the lymph from many vital organs: the next most commonly biopsied nodes are ...