Growing concerns about the wellbeing and stability of the biomedical research workforce are well documented. Over the last 15 years (since the end of the doubling of the NIH budget), we have observed worsening “hypercompetition” as more scientists vie for fewer available dollars (1, 2). Within this hypercompetitive environment, the research workforce is growing older at a rate that is dispropor...

INTRODUCTION Pilot studies are meritorious for determining the feasibility of a definitive clinical trial in terms of conduct and potential for efficacy, but their possible applications for planning a future trial are not always fully realized. The purpose of this review was to estimate the extent to which pilot/feasibility studies: (i) addressed needed objectives; (ii) led to definitive trials...

We begin with the premise that private class actions for money damages can yield significant social benefits. Class actions for damages can provide compensation for modest but non-trivial losses suffered by widely dispersed but similarly positioned persons as a result of the negligence or illegal behavior of others, allowing recovery for losses that cannot practically be achieved through indivi...

The annotation of protein function is a vital step to elucidate the essence of life at a molecular level, and it is also meritorious in biomedical and pharmaceutical industry. Developments of sequencing technology result in constant expansion of the gap between the number of the known sequences and their functions. Therefore, it is indispensable to develop a computational method for the annotat...

A journal can only be as good as its reviewers. The Editors of Circulation Research wish to acknowledge the following reviewers, who have distinguished themselves for exemplary performance and outstanding contributions to the journal. They have selflessly donated their time (often on weekends and evenings), their energy, and their expertise to assist the editors in the difficult task of selecti...

symposium agree with my concept. Many of the essays are concerned chiefly with clinical chemistry, as reflected in how to do urine tests or interpret blood studies. Considerable portions of certain chapters are devoted to purely practical applications of clinical tests (e.g. of liver function) without any consideration of their biochemical significance. In spite of these editorial criticisms, t...

In today’s era of plasma and laser cutting, machines using oxy-acetylene flame are also meritorious due to their simplicity and cost effectiveness. The objective to devise a Computer controlled Oxy-Fuel profile cutting machine arose from the increasing demand for metal cutting with respect to edge quality, circularity and lesser formation of redeposit material. The System has an 8 bit micro con...

Every linguist dreams of the day when the intricate variety of human language will be a commonplace, widely understood in our own and other cultures; when we can unlock the secrets of human thought and communication; when people will stop asking us how many languages we speak. This day has not yet arrived; but the present book brings it somewhat closer. It is, to begin with, a very attractive b...

This work explores the automatic recognition of physical activity intensity patterns from multi-axial accelerometry and heart rate signals. Data collection was carried out in free-living conditions and in three controlled gymnasium circuits, for a total amount of f 79.80 h of data divided into: sedentary situations (65.5%), light-to-moderate activity (17.6%) and vigorous exercise (16.9%). The p...

The present study considers mathematical classification of the time differential operators and then applies methods of approximation in time such as Galerkin method ( GM ), Galerkin method with weak form ( / GM WF ), Petrov-Galerkin method ( PGM ), weighted residual method (WRY ), and least squares method or process ( LSM or LSP ) to construct finite element approximations in time. A correspond...